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(-)-Blebbistatin

Cat. No. M2459

All AbMole products are for research use only, cannot be used for human consumption.

(-)-Blebbistatin Structure
Synonym:

(S)-(-)-Blebbistatin

Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 120  USD120 In stock
25mg USD 235  USD235 In stock
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Quality Control & Documentation
Biological Activity

Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.

*The compound is unstable in solutions, freshly prepared is recommended

Product Citations
Chemical Information
Molecular Weight 292.33
Formula C18H16N2O2
CAS Number 856925-71-8
Solubility (25°C) DMSO 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Wener Li, et al. Blebbistatin protects iPSC-CMs from hypercontraction and facilitates automated patch-clamp based electrophysiological study

[2] Song Gao, et al. Blebbistatin Inhibits Neomycin-Induced Apoptosis in Hair Cell-Like HEI-OC-1 Cells and in Cochlear Hair Cells

[3] Yuanyuan Zhang, et al. An inhibitor of myosin II, blebbistatin, suppresses development of arterial thrombosis

[4] Anna Rauscher, et al. Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential

[5] Bart I Roman, et al. Medicinal Chemistry and Use of Myosin II Inhibitor ( S)-Blebbistatin and Its Derivatives

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Keywords: (-)-Blebbistatin, (S)-(-)-Blebbistatin supplier, Myosin, inhibitors, activators

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