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TR100 is a specific anti-tropomyosin agent that preferentially disrupts the actin cytoskeleton of tumor cells. TR100 selectively disrupts Tm5NM1/2 containing actin filaments. TR100 induces apoptosis in a panel of neural crest-derived tumor cell lines with no adverse effects on cardiac structure and function.
| Molecular Weight | 422.61 |
| Formula | C26H38N4O |
| CAS Number | 1128165-86-5 |
| Solubility (25°C) | DMSO: 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Anthony J Kee, et al. On-target action of anti-tropomyosin drugs regulates glucose metabolism
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