All AbMole products are for research use only, cannot be used for human consumption.
Mavacamten, also known as SAR-439152 and MYK-461, is a first-in-class myosin inhibitor potentially for the treatment of hypertrophic cardiomyopathy. Mavacamten has IC50 values of 490, 711 nM for bovine cardiac and human cardiac, respectively. Mavacamten (SAR-439152) reduces contractility by decreasing the adenosine triphosphatase activity of the cardiac myosin heavy chain. MYK-461 reduces cardiac contractility, prevents left ventricular hypertrophy, and reverses pathologic remodeling. In cats, it relieves left ventricular outflow tract obstruction.
| Molecular Weight | 273.33 |
| Formula | C15H19N3O2 |
| CAS Number | 1642288-47-8 |
| Solubility (25°C) | DMSO 65 mg/mL |
| Storage | -20°C, sealed |
| Related Myosin Products |
|---|
| Ulacamten
Ulacamten is a potent cardiac myosin inhibitor. |
| Myosin Light Chain Kinase Substrate (smooth muscle)
Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate. |
| Kemptamide
Kemptamide, a 13 amino acid fragment with a sequence corresponding to residues 11-23 of gizzard light chain. |
| MYK-224
MYK-224 is a cardiac myosin complex modulator that can be used in studies related to cardiovascular disease. |
| Myosin V-IN-1
Myosin V-IN-1 is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
