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Danicamtiv (MYK-491, SAR 440181) is a novel and selective cardiac myosin allosteric activator that enhances cardiomyocyte contraction. Danicamtiv selectively enhances cardiac actomyosin activity, the molecular force‐generating unit of the sarcomere, prolonging contraction while preserving actin–myosin detachment, allowing relaxation, and without impacting Ca2+ homeostasis.
| Molecular Weight | 435.42 |
| Formula | C16H20F3N5O4S |
| CAS Number | 1970972-74-7 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Myosin Products |
|---|
| Ulacamten
Ulacamten is a potent cardiac myosin inhibitor. |
| Myosin Light Chain Kinase Substrate (smooth muscle)
Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate. |
| Kemptamide
Kemptamide, a 13 amino acid fragment with a sequence corresponding to residues 11-23 of gizzard light chain. |
| MYK-224
MYK-224 is a cardiac myosin complex modulator that can be used in studies related to cardiovascular disease. |
| Myosin V-IN-1
Myosin V-IN-1 is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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