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Benazepril hydrochloride

Cat. No. M5447
Benazepril hydrochloride Structure
Synonym:

CGS 14824A HCl

Size Price Availability Quantity
200mg USD 50  USD50 In stock
500mg USD 75  USD75 In stock
1g USD 115  USD115 In stock
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Quality Control & Documentation
Biological Activity

Benazepril hydrochloride is an angiotensin converting enzyme (ACE) inhibitor.

Chemical Information
Molecular Weight 460.95
Formula C24H28N2O5.HCl
CAS Number 86541-74-4
Form Solid
Solubility (25°C) 92 mg/mL in DMSO
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lantis AC, et al. J Vet Pharmacol Ther. Aldosterone breakthrough with benazepril in furosemide-activated renin-angiotensin-aldosterone system in normal dogs.

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Keywords: Benazepril hydrochloride, CGS 14824A HCl supplier, ACE, inhibitors, activators


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