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Ramipril (Altace) is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5 nM. It is used to treat hypertension and congestive heart failure. ACE inhibitors lower the production of angiotensin II, therefore relaxing arterial muscles while at the same time enlarging the arteries, allowing the heart to pump blood more easily, and increasing blood flow due to more blood being pumped into and through larger passageways.
| Cell Experiment | |
|---|---|
| Cell lines | Human umbilical vein endothelial cells (HUVECs) |
| Preparation method | Pretreating the HUVECs with the active metabolites of Ramipril for 24 hours. Usinf a serum deprivation method to induce apoptosis in the presence of Ramipril for an additional 24 hours. Then determining the rate of apoptosis using flow cytometry with two makers annexinV fluorescein isothiocyanate (FITC+) and propidium iodide (PI). |
| Concentrations | ~1 μM |
| Incubation time | 24 hours |
| Animal Experiment | |
|---|---|
| Animal models | Male spontaneously hypertensive rats |
| Formulation | Dissolved in distilled water by using gum arabic (10% w/v) |
| Dosages | 0.03-10 mg/kg |
| Administration | Gavage, every day |
| Molecular Weight | 416.51 |
| Formula | C23H32N2O5 |
| CAS Number | 87333-19-5 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ACE Products |
|---|
| Temocapril
Temocapril is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension. |
| Imidapril hydrochloride
Imidapril hydrochloride is a angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension. Imidapril hydrochloride inhibits lipopolysaccharide-induced phosphorylation of c-Jun, MKK4 and JNK in monocytes, and downregulates the production of specific inflammatory factors such as TNF-α and IP-10, thereby exerting anti-inflammatory activity. |
| Perindopril Erbumine
Perindopril Erbumine is a potent ACE inhibitor with IC50 of 1.05 nM. |
| Quinapril hydrochloride
Quinapril hydrochloride is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM. |
| Zofenopril calcium
Zofenopril Calcium is an antioxidant that acts as an angiotensin-converting enzyme （ACE）inhibitor. |
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