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Enalapril Maleate

Cat. No. M3543

All AbMole products are for research use only, cannot be used for human consumption.

Enalapril Maleate Structure
Synonym:

MK-421 Maleate

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 30  USD30 In stock
500mg USD 30  USD30 In stock
1g USD 45  USD45 In stock
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Quality Control & Documentation
Biological Activity

Enalapril maleate (Vasotec), the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Enalaprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.

Chemical Information
Molecular Weight 492.52
Formula C20H28N2O5.C4H4O4
CAS Number 76095-16-4
Solubility (25°C) Water ≥ 10 mg/mL
DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gabriel R Estrela, et al. Front Mol Biosci. Angiotensin-Converting Enzyme Inhibitor Protects Against Cisplatin Nephrotoxicity by Modulating Kinin B1 Receptor Expression and Aminopeptidase P Activity in Mice

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Keywords: Enalapril Maleate, MK-421 Maleate supplier, ACE, inhibitors, activators

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