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Pemigatinib

Cat. No. M9596
Pemigatinib Structure
Synonym:

INCB054828

Size Price Availability Quantity
2mg USD 90  USD90 In stock
5mg USD 120  USD120 In stock
10mg USD 180  USD180 In stock
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Quality Control
Biological Activity

Pemigatinib (INCB054828) is an orally bioavailable inhibitor of FGFR with IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Pemigatinib binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 487.5
Formula C24H27F2N5O4
CAS Number 1513857-77-6
Purity 99.79%
Solubility DMSO ≥ 32 mg/mL
Storage at -20°C
References

[1] Robert Roskoski Jr. Pharmacol Res. The Role of Fibroblast Growth Factor Receptor (FGFR) Protein-Tyrosine Kinase Inhibitors in the Treatment of Cancers Including Those of the Urinary Bladder

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Keywords: Pemigatinib, INCB054828 supplier, FGFR, inhibitors

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