| Cat.No. | Name | Information |
|---|---|---|
| M6189 | Ossirene | Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta (IL-1β) converting enzyme. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene also inhibits Caspase-1. |
| M6223 | Tocilizumab | Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor. Tocilizumab prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab can be used for the research of rheumatoid arthritis and COVID-19. |
| M10139 | Anakinra | Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. |
| M1622 | Secukinumab | Secukinumab (AIN457) is a high-affinity monoclonal antibody against interleukin (IL-17A). Secukinumab (AIN457) is the first-in-class anti-IL-17 agent to be used in studies of plaque psoriasis, ankylosing spondylitis, and psoriatic arthritis. |
| M3001 | SC144 | SC144 is the first oral active GP130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, eliminates Stat3 phosphorylation and nuclear translocation, and further inhibits downstream target gene expression. SC144 inhibited signal transduction induced by GP130 ligand. SC144 induces apoptosis of human ovarian cancer cells. |
| M2629 | Diacerein | Diacerin is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis. |
| M2594 | Montelukast sodium | Montelukast sodium selectively antagonizes leukotriene D 4 (LTD4) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1. |
| M2559 | VGX-1027 | VGX-1027 is an orally active immunomodulator. |
| M1621 | Ustekinumab | Ustekinumab is a human monoclonal antibody that targets IL12 and IL23, natural proteins that regulate the immune system and immune-mediated inflammatory diseases. |
| M58640 | IL-17A modulator-2 | IL-17A modulator-2 is a IL-17A modulator. IL-17A modulator-2 inhibits the biological action of IL-17A with a pIC50 of 8.3. IL-17A modulator-2 can be used for the research of diseases associated with modulation of IL-17A activity. |
| M56367 | IL-15-IN-1 | IL-15-IN-1 is a potent and selective Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM. |
| M56366 | IL-17 modulator 3 | IL-17 modulator 3 is an IL-17 modulator. |
| M56364 | IL-17A modulator-3 | IL-17A modulator-3 is a IL-17A modulator. |
| M56363 | IL-17 modulator 4 sulfate | IL-17 modulator 4 sulfate is a proagent of IL-17 modulator 1. |
| M55322 | LY3471851 | LY3471851 (Rezpegaldesleukin, NKTR-358) is a novel, first-in-class selective regulatory T-cell (Treg) inducing IL-2 conjugate. |
| M54690 | HB0017 | HB0017 is a monoclonal antibody that targets interleukin-17 (IL-17) and selectively binds IL-17A, thereby preventing IL-1717A from binding to its receptor. |
| M54550 | Stapokibart | Stapokibart is a humanized monoclonal antibody targeting IL-4Rα that blocks the interaction of cytokines IL-4 and IL-13 with their co-receptor subunit, IL-4Rα. Stapokibart is able to interact with IL-4Rα in humans, cynomolgus monkeys, and rats, and can be used in atopic dermatitis research. |
| M54008 | AF12198 | AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). |
| M52856 | Antiflammin-1 | Antiflammin-1 is an anti-inflammatory peptide 1 (MQMKKVLDS). |
| M52855 | β-Interleukin II (44-56) | β-Interleukin II (44-56) is a 44-56 fragment of beta-interleukin II polypeptide. |
| M52854 | Interleukin II (60-70) | Interleukin II (60-70) is a 60-70 fragment of the cytokine Interleukin II polypeptide. |
| M52853 | Acetyl hexapeptide-49 | Acetyl hexapeptide-49 is a bioactive peptide with anti-allergen effect and has been reported used as a cosmetic ingredient. |
| M52852 | Myelopeptide-2 | Myelopeptide-2 is a peptide which can restore mitogenic reactivity of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus conditions. |
| M52851 | Romurtide | Romurtide (Muroctasin), a synthetic muramyl dipeptide derivative, is a cytokines inducer. |
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