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JTE 607 dihydrochloride is a cytokine release inhibitor. JTE 607 dihydrochloride inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα from LPS-stimulated PBMCs with IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively. JTE 607 dihydrochloride reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. JTE-607 induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.
| Molecular Weight | 597.36 |
| Formula | C25H31Cl2N3O5.2HCl |
| CAS Number | 188791-09-5 |
| Solubility (25°C) | DMSO 100 mg/mL Water ≥ 20 mg/mL |
| Storage | -20°C, dry, sealed |
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