Cat.No. | Name | Information |
---|---|---|
M10139 | Anakinra | Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. |
M6223 | Tocilizumab | Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor, MW: 148 KD. |
M6189 | Ossirene (AS101) | Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme. |
M40795 | Anti-Mouse IL-4 In vivo | IL-4 antibody, 11B11, recognizes mouse IL-4, also known as B-cell differentiation factor (BCDF) and B-cell stimulatory factor (BSF1). |
M30835 | Lipoxin A4 | Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM. |
M24793 | Simlukafusp alfa | Simlukafusp alfa (FAP-IL2v) is an immunocytokine comprising an antibody against fibroblast activation protein α (FAPα) and an IL-2 variant that only binds IL-2Rβγ. Isotype: human IgG1. |
M22522 | IL-17A inhibitor 1 | IL-17A inhibitor 1 is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells. |
M21628 | 2'-Fucosyllactose | 2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines. |
M21444 | GP130 receptor agonist-1 | GP130 receptor agonist-1 is a potent, brain-penetrant and orally active GP130 receptor agonist. GP130 receptor agonist-1 has a neuroprotective effect on NMDA-induced neurotoxicity. |
M20846 | Hydrocortisone sodium succinate | Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators. |
M20724 | RCM-1 | RCM-1 is a nontoxic inhibitor of Forkhead box M1 (FOXM1) that suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. RCM-1 decreases carcinogenesis and nuclear β-catenin. |
M20539 | Montelukast | Montelukast is a potent, selective and orally active cysteinyl leukotriene receptor 1 (CysLT1) antagonist with antioxidant activity for studies related to asthma and liver injury. |
M11349 | Deoxyandrographolide | Deoxyandrographolide inhibited lPS-induced iNOS mRNA and the production of pro-inflammatory mediators TNF-α and IL-6. Deoxyandrographolide enhances neurite growth induced by NGF. |
M11086 | RCGD423 | RCGD423 is a gp130 regulator that prevents joint cartilage degeneration and promotes its repair. |
M10686 | Muscone | Muscone is the main active monomer of Chinese medicinal musk. Muscone inhibits activation of NF-κB and NLRP3 inflammatory bodies. Muscone significantly lowers inflammatory cytokine (IL-1β, TNF-α, and IL-6) levels and ultimately improves heart function and survival. |
M10559 | Tyrphostin A1 | Tyrphostin A1 is a weaker EGFR tyrosine kinase inhibitor, Tyrphostin A1 inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. |
M10159 | Kaempferol 3-O-β-D-glucuronide | Kaempferol 3-O-β-D-glucuronide is a conjugated kaempferol metabolite, which has anti-inflammatory effect. |
M9868 | GIBH-130 | GIBH-130 is a neuroinflammation inhibitor, with IC50 value of 3.4 nM for suppressing the IL-1β secretion by activated microglia. |
M9418 | Apilimod mesylate | Apilimod mesylate is a potent IL-12/IL-23 inhibitor, which inhibits the IL-12 production in cultures of IFN-γ/LPS–stimulated human PBMCs with an IC50 of 10 nM. |
M9247 | YM-90709 | YM-90709 is an interleukin-5 receptor antagonist. |
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