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Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin.
| CAS Number | 914613-48-2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[4] Naomi Schlesinger. Expert Opin Biol Ther. Canakinumab in gout
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