| Cat.No. | Name | Information |
|---|---|---|
| M6189 | Ossirene | Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta (IL-1β) converting enzyme. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene also inhibits Caspase-1. |
| M6223 | Tocilizumab | Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor. Tocilizumab prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab can be used for the research of rheumatoid arthritis and COVID-19. |
| M10139 | Anakinra | Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. |
| M9418 | Apilimod mesylate | Apilimod mesylate is a potent IL-12/IL-23 inhibitor, which inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively Apilimod is also a potent and highly selective PIKfyve inhibitor. |
| M9247 | YM-90709 | YM-90709 is an interleukin-5 receptor antagonist. |
| M8591 | LMT-28 | LMT-28 is an IL-6 antagonist that targets the IL-6 Receptor β subunit, Glycoprotein 130 (gp130). |
| M7273 | SC 144 hydrochloride | SC144 hydrochloride is the first oral active GP130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, inducing phosphorylation (S782) and deglycosylation of GP130, eliminating Stat3 phosphorylation and nuclear translocation, and further inhibiting the expression of downstream target genes. SC144 hydrochloride inhibited signal transduction induced by GP130 ligand. SC144 hydrochloride induces apoptosis of human ovarian cancer cells. |
| M6852 | JTE 607 dihydrochloride | JTE 607 dihydrochloride is a highly selective inflammatory cytokine synthesis inhibitor with anti-inflammatory effect. |
| M6382 | Smurf1-IN-A01 | Smurf1-IN-A01 is a high affinity Smurf1 inhibitor; enhances BMP signaling. |
| M5444 | Balsalazide | Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. |
| M4689 | Pectolinarin | Pectolinarin has anti-inflammatory activity. Pectolinarin inhibits il-6 and IL-8 secretion and PGE2 and NO production. Pectolinarin can inhibit cell proliferation and inflammatory response and induce apoptosis by inhibiting PI3K/Akt pathway. |
| M4636 | Desacetyl-asperulosidic-acid | Deacetylasperulosidic acid (DAA) is the main phytochemical component of Morinda Citrifolia fruit. |
| M4528 | Rosarin | Rosarin is a cinnamyl glycoside isolated from rhodiola rosea. Rosarin has anti-inflammatory and neuroprotective effects. Rosarin inhibited the expression of iNOS, IL-1β and TNF-α in the kidney and prefrontal cortex of mice. |
| M4085 | Ginsenoside-F3 | Ginsenoside F3, a saponin extracted from Panax ginseng leaves, exerts immune-enhancing activity by regulating the production and expression of il-2 (IFN-γ) and IL-4 and IL-10. |
| M3814 | Sarilumab | Sarilumab is a human recombinant IgG1 antibody that binds to both forms of interleukin 6 receptors (IL-6R), thus inhibiting the IL-6-mediated signaling. |
| M3537 | Suplatast Tosylate | Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM. |
| M3001 | SC144 | SC144 is the first oral active GP130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, eliminates Stat3 phosphorylation and nuclear translocation, and further inhibits downstream target gene expression. SC144 inhibited signal transduction induced by GP130 ligand. SC144 induces apoptosis of human ovarian cancer cells. |
| M2594 | Montelukast sodium | Montelukast sodium selectively antagonizes leukotriene D 4 (LTD4) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1. |
| M2559 | VGX-1027 | VGX-1027 is an orally active immunomodulator. |
| M1622 | Secukinumab | Secukinumab (AIN457) is a high-affinity monoclonal antibody against interleukin (IL-17A). Secukinumab (AIN457) is the first-in-class anti-IL-17 agent to be used in studies of plaque psoriasis, ankylosing spondylitis, and psoriatic arthritis. |
| M1621 | Ustekinumab | Ustekinumab is a human monoclonal antibody that targets IL12 and IL23, natural proteins that regulate the immune system and immune-mediated inflammatory diseases. |
| M56367 | IL-15-IN-1 | IL-15-IN-1 is a potent and selective Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM. |
| M56366 | IL-17 modulator 3 | IL-17 modulator 3 is an IL-17 modulator. |
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