| Cat.No. | Name | Information |
|---|---|---|
| M6189 | Ossirene (AS101) | Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme. |
| M6223 | Tocilizumab | Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor, MW: 148 KD. |
| M10139 | Anakinra | Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. |
| M8591 | LMT-28 | LMT-28 is an IL-6 antagonist that targets the IL-6 Receptor β subunit, Glycoprotein 130 (gp130). |
| M7273 | SC 144 hydrochloride | SC144 hydrochloride is the first oral active GP130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, inducing phosphorylation (S782) and deglycosylation of GP130, eliminating Stat3 phosphorylation and nuclear translocation, and further inhibiting the expression of downstream target genes. SC144 hydrochloride inhibited signal transduction induced by GP130 ligand. SC144 hydrochloride induces apoptosis of human ovarian cancer cells. |
| M6852 | JTE 607 dihydrochloride | JTE 607 dihydrochloride is a highly selective inflammatory cytokine synthesis inhibitor with anti-inflammatory effect. |
| M5444 | Balsalazide | Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. |
| M4689 | Pectolinarin | Pectolinarin has anti-inflammatory activity. Pectolinarin inhibits il-6 and IL-8 secretion and PGE2 and NO production. Pectolinarin can inhibit cell proliferation and inflammatory response and induce apoptosis by inhibiting PI3K/Akt pathway. |
| M4636 | Desacetyl-asperulosidic-acid | Deacetylasperulosidic acid (DAA) is the main phytochemical component of Morinda Citrifolia fruit. |
| M4528 | Rosarin | Rosarin is a cinnamyl glycoside isolated from rhodiola rosea. Rosarin has anti-inflammatory and neuroprotective effects. Rosarin inhibited the expression of iNOS, IL-1β and TNF-α in the kidney and prefrontal cortex of mice. |
| M4085 | Ginsenoside-F3 | Ginsenoside F3, a saponin extracted from Panax ginseng leaves, exerts immune-enhancing activity by regulating the production and expression of il-2 (IFN-γ) and IL-4 and IL-10. |
| M3537 | Suplatast Tosylate | Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM. |
| M3001 | SC144 | SC144 is the first oral active GP130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, eliminates Stat3 phosphorylation and nuclear translocation, and further inhibits downstream target gene expression. SC144 inhibited signal transduction induced by GP130 ligand. SC144 induces apoptosis of human ovarian cancer cells. |
| M2594 | Montelukast sodium | Montelukast sodium selectively antagonizes leukotriene D 4 (LTD4) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1. |
| M2559 | VGX-1027 | VGX-1027 is an orally active immunomodulator. |
| M1622 | Secukinumab | Secukinumab (AIN457) is a high-affinity monoclonal antibody against interleukin (IL-17A). Secukinumab (AIN457) is the first-in-class anti-IL-17 agent to be used in studies of plaque psoriasis, ankylosing spondylitis, and psoriatic arthritis. |
| M1621 | Ustekinumab | Ustekinumab is a human monoclonal antibody that targets IL12 and IL23, natural proteins that regulate the immune system and immune-mediated inflammatory diseases. |
| M54690 | HB0017 | HB0017 is a monoclonal antibody that targets interleukin-17 (IL-17) and selectively binds IL-17A, thereby preventing IL-1717A from binding to its receptor. |
| M54551 | Rademikibart | Rademikibart is a human IgG4ҡ monoclonal antibody that targets IL-4 Rα to block inflammatory signaling induced by IL-4 and IL-13, two important cytokines that drive allergic inflammation, and binds to the human IL-4Rα epitope with a KD of 20.7 pM. Rademikibart does not bind to IL-4Rα from other species. Rademikibart does not bind to IL-4Rα of other species.Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation, and TARC production in PBMC, and can be used in studies related to moderate-to-severe Th2 inflammatory diseases. |
| M54550 | Stapokibart | Stapokibart is a humanized monoclonal antibody targeting IL-4Rα that blocks the interaction of cytokines IL-4 and IL-13 with their co-receptor subunit, IL-4Rα. Stapokibart is able to interact with IL-4Rα in humans, cynomolgus monkeys, and rats, and can be used in atopic dermatitis research. |
| M54371 | Erepdekinra | Erepdekinra is an interleukin-17A (IL-17A) receptor antagonist. |
| M54008 | AF12198 | AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). |
| M53841 | Ac-YVAD-CHO | Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. |
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