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Sarilumab is a human recombinant IgG1 antibody that binds to both forms of interleukin 6 receptors (IL-6R), thus inhibiting the IL-6-mediated signaling. IL-6 is known to be a pleiotropic cytokine that activates immune cells (T and B cells), as well as hepatocytes for the release of acute phase proteins like CRP, serum amyloid A and fibrinogen which are biomarkers of RA activity. IL-6 is also found in synovial fluid and plays a major role in the pathological inflammation and joint destruction features of RA. Sarilumab is used for the treatment of RA due to its ability to inhibit intra-articular and systemic IL-6 signaling.
| Formula | C6388H9918N1718O1998S44 |
| CAS Number | 1189541-98-7 |
| Solubility (25°C) | PBS buffer |
| Storage | 4°C, protect from light |
[2] Sajad Khiali, et al. A comprehensive review on sarilumab in COVID-19
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