Deacetylasperulosidic acid (DAA) is the main phytochemical component of Morinda Citrifolia fruit. Deacetylasperulosidic acid has antioxidant activity by increasing superoxide dismutase activity. Deacetylasperulosidic acid has antigenic activity and inhibits the induction of chromosomal aberrations in hamster ovary cells and mice. Deacetylasperulosidic acid prevents DNA damage induced by 4-nitroquinoline 1-oxide (4NQO) in vitro, inhibits IL-2 production and activation of natural killer cells.
| Molecular Weight | 390.34 |
| Formula | C16H22O11 |
| CAS Number | 14259-55-3 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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