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Apilimod mesylate is a potent IL-12/IL-23 inhibitor, which inhibits the IL-12 production in cultures of IFN-γ/LPS–stimulated human PBMCs with an IC50 of 10 nM. Apilimod mesylate inhibited IFN-γ production induced by either IFN-γ/SAC or SAC in human PBMCs, with an IC50 of approximately 20 nM.
In vivo, oral administration of either 5 mg/kg or 20 mg/kg Apilimod mesylate (STA-5326) reduced the severity of EAU on day 14 and 18. In addition, mice treated with 20 mg/kg STA-5326 showed significantly decreased severity of EAU by histopathological analysis.
| Molecular Weight | 610.7 |
| Formula | C25H34N6O8S2 |
| CAS Number | 870087-36-8 |
| Solubility (25°C) | Water 60 mg/mL DMSO 8 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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