All AbMole products are for research use only, cannot be used for human consumption.
Smurf1-IN-A01 is a high affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM). Smurf1-IN-A01 attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Smurf1-IN-A01 potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.
| Molecular Weight | 512.93 |
| Formula | C22H20ClF3N4O3S |
| CAS Number | 1007647-73-5 |
| Solubility (25°C) | DMSO 51.29 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Sai Shi, et al. Molecular mechanism of CaCC inh-A01 inhibiting TMEM16A channel
[4] No authors listed. J Cereb Blood Flow Metab. Poster Viewing Sessions PA00-A01 to PA00-A49
| Related IL Receptor/Related Products |
|---|
| IL-17A modulator-2
IL-17A modulator-2 is a IL-17A modulator. IL-17A modulator-2 inhibits the biological action of IL-17A with a pIC50 of 8.3. IL-17A modulator-2 can be used for the research of diseases associated with modulation of IL-17A activity. |
| IL-15-IN-1
IL-15-IN-1 is a potent and selective Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM. |
| IL-17 modulator 3
IL-17 modulator 3 is an IL-17 modulator. |
| IL-17 modulator 4
IL-17 modulator 4 is a proagent of IL-17 modulator 1. IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. IL-17 modulator 4 is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome. |
| IL-17A modulator-3
IL-17A modulator-3 is a IL-17A modulator. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
