| Cat.No. | Name | Information |
|---|---|---|
| M9075 | Etomoxir sodium salt | Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig. |
| M10566 | Valepotriate | Valepotriate has anti-epileptic and anti-cancer activities, it isolated from Valeriana jatamansi Jones. |
| M7755 | Dehydroleucodine | Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana Besser; mast cell stabilizers. |
| M7622 | BI-6C9 | BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons. |
| M7576 | Importazole | Importazole is a small molecule inhibitor of the nuclear transport receptor importin-β. |
| M7419 | Toyocamycin | Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin is a adenosine analog; antifungal antibiotic. |
| M7341 | Swainsonine | Swainsonine is a potent inhibitor of α-mannosidase II. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. |
| M7145 | Pladienolide B | Pladienolide B is a potent pre-mRNA splicing inhibitor, exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B induces apoptosis. |
| M6673 | DIM-C-pPhOH | DIM-C-pPhOH (C-DIM8, CDIM8) is a nur77 antagonist. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively. |
| M6567 | CCCP | CCCP is a oxidative phosphorylation uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation. |
| M6553 | C16 | C16 is a pKR inhibitor. |
| M6313 | PTC-028 | PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1, it downregulates BMI-1, inducing caspase-mediated apoptosis. PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification. |
| M6290 | Puromycin aminonucleoside | Puromycin aminonucleoside (PAN), which is an analogue of puromycin antibiotic, has been largely adopted to experimentally induce MCD in rodents (with a single high dose) or FSGS (by repeated doses for over a longer period). |
| M6257 | ONC212 | The ClpP activator ONC‐212 (TR‐31), a fluorinated-ONC201 analogue, is broadly efficacious across most solid tumors and hematological malignancies in the low nanomolar range and has robust anti-leukemic activity. |
| M5934 | Risedronate sodium | Risedronic acid (Risedronate) sodium, a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid sodium suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. |
| M5843 | Oxybenzone | Oxybenzone (Benzophenone 3) is a benzophenone derivative acts as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells. |
| M5761 | Mangafodipir trisodium | Mangafodipir is a contrast agent delivered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver. |
| M5689 | Hesperidin | Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols. |
| M5636 | Etretinate | Etretinate is an orally available aromatic retinoid that has been shown to be effective in studies of cow skin and other skin syndromes. It can activate retinoid receptor, induce cell differentiation, inhibit cell proliferation and inhibit tissue infiltration. |
| M5632 | Etidronate | Etidronate is a class of non-aminobisphosphate that inhibits human protein tyrosine phosphatase activity and is used in the study of Paget's disease and in the prevention of ectopic ossification. |
| M5623 | Escin | Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut). |
| M5568 | Diatrizoic acid | Diatrizoic Acid is an organic, iodinated radiocontrast agent used in diagnostic radiography. |
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