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Under hypoxic conditions, tirapazamine is a potent cytotoxic agent that induces apoptosis by inducing breaks in single and double stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin.
| Molecular Weight | 178.15 |
| Formula | C7H6N4O2 |
| CAS Number | 27314-97-2 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Prafull Ghatage, et al. Is there a role for tirapazamine in the treatment of cervical cancer?
[3] Loredana Marcu, et al. Tirapazamine: from bench to clinical trials
[4] W A Denny, et al. Tirapazamine: a bioreductive anticancer drug that exploits tumour hypoxia
[5] U Gatzemeier, et al. Tirapazamine-cisplatin: the synergy
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