Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M8807 | Perillaldehyde | Perillaldehyde inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway. |
| M7727 | CH-223191 | CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM. *The compound is unstable in solutions, freshly prepared is recommended |
| M56338 | AHR antagonist 5 free base | AHR antagonist 5 free base is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. |
| M38970 | Benzyl butyl phthalate | Benzyl butyl phthalate can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs). |
| M31143 | Indole-3-ylacetaldehyde | Indole-3-ylacetaldehyde (I3A) |
| M25533 | Carbidopa monohydrate | Carbidopa monohydrate is a dopa decarboxylase (DDC) inhibitor, which can be used for the research of Parkinson's disease. Carbidopa monohydrate is also a selective aryl hydrocarbon receptor (AhR) modulator. |
| M25481 | β-Naphthoflavone | β-Naphthoflavone is an aryl hydrocarbon receptor (AhR) agonist, used as a positive control for the induction of AhR transcriptional activity. β-Naphthoflavone inhibits hydrogen peroxide-induced apoptosis. |
| M20602 | UM729 | UM729 is an enhancer of aryl hydrocarbon receptor (AhR) antagonists. |
| M11147 | Skatole | Skatole is a substance produced by the intestinal flora that regulates intestinal epithelial cell function by activating aryl hydrocarbon receptors and p38. |
| M10941 | Tapinarof | Tapinarof (WBI-1001) is a Frist in class aromatic hydrocarbon receptor (AhR) agonist with EC50 of 13 nM. Tapinarof reduced skin inflammation in mice. It can effectively inhibit inflammatory cytokines, regulate skin barrier protein expression and antioxidant activity. |
| M10486 | GNF351 | GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. |
| M10243 | D-Kynurenine | D-kynurenine is a metabolite of D-tryptophan, which can be used as a biological precursor of KYNA and 3-hydroxykynurenine. |
| M9723 | L-Kynurenine | L-Kynurenine is an aryl hydrocarbon receptor agonist. |
| M9714 | CAY10465 | CAY10465 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor agonist, with a Ki of 0.2 nM. |
| M9693 | PDM2 | PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM. |
| M9490 | YL-109 | YL-109 is a novel anticancer agent, which can inhibit breast cancer cell growth and invasiveness in vitro and in vivo, YL-109 is also an STUB1 enhancer. |
| M9087 | FICZ | FICZ is a potent aryl hydrogen receptor (AhR) agonist, with a Kd of 70 pM. FICZ acts by inducing transient expression of cytochrome P450-1A1 (CYP1A1) in vitro. |
| M8862 | YH439 | Mivotilate (YH439) is a potent activator of the aryl hydrocarbon receptor (AhR). |
| M4783 | Diosimin | Diosimin is a flavonoid glycoside found in citrus fruits, hyssop, and rosemary. |
| M3260 | Carbidopa | Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM. |
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