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Cat. No. M10243
D-Kynurenine Structure
Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 120  USD120 In stock
25mg USD 240  USD240 In stock
50mg USD 360  USD360 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

D-kynurenine is a metabolite of D-tryptophan, which can be used as a biological precursor of KYNA and 3-hydroxykynurenine.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 208.21
Formula C10H12N2O3
CAS Number 13441-51-5
Purity >98.5%
Solubility Water 60 mg/mL
Storage at -20°C

[1] Peter J Siska, et al. EBioMedicine. Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo

[2] Zhiqing Duan, et al. Mol Cell Biochem. Promoting epithelial-to-mesenchymal transition by D-kynurenine via activating aryl hydrocarbon receptor

[3] Francesca M Notarangelo, et al. J Neurochem. Role of d-amino acid oxidase in the production of kynurenine pathway metabolites from d-tryptophan in mice

[4] Xiao-Dan Wang, et al. Anal Bioanal Chem. A method for the determination of D-kynurenine in biological tissues

[5] Veronica Prez-de la Cruz, et al. J Neurochem. Enzymatic transamination of D-kynurenine generates kynurenic acid in rat and human brain

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Abmole Inhibitor Catalog 2017

Keywords: D-Kynurenine supplier, AhR, inhibitors

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