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D-kynurenine is a metabolite of D-tryptophan, which can be used as a biological precursor of KYNA and 3-hydroxykynurenine. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR). D-Kynurenine is an agonist for G protein-coupled receptor GPR109B.
| Molecular Weight | 208.21 |
| Formula | C10H12N2O3 |
| CAS Number | 13441-51-5 |
| Solubility (25°C) | Water 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Aryl hydrocarbon Receptor Products |
|---|
| AHR antagonist 5
AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist, has an IC50 of < 0.5 µΜ. |
| AHR antagonist 5 free base
AHR antagonist 5 free base is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. |
| KYN-101
KYN-101 is a potent, selective and orally active AHR inhibitor. |
| AHR agonist 4
AHR agonist 4 is an agonist of Aryl hydrocarbon receptor (AHR), assocaited with the immune balance of Th17/22 and Treg cells. |
| Benzyl butyl phthalate
Benzyl butyl phthalate can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs). |
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