Free shipping on all orders over $ 500

GNF351

Cat. No. M10486
GNF351 Structure
Size Price Availability Quantity
10mg USD 180  USD180 In stock
25mg USD 360  USD360 In stock
50mg USD 660  USD660 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 (500 nM, 48 hours) significantly reduces the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 411.5
Formula C24H25N7
CAS Number 1227634-69-6
Purity >99%
Solubility DMSO ≥ 90 mg/mL
Storage at -20°C
References

[1] Shusuke Ozawa, et al. Life Sci. Expression profile of cytochrome P450s and effects of polycyclic aromatic hydrocarbons and antiepileptic гυgs on CYP1 expression in MOG-G-CCM cells

[2] Ellen H van den Bogaard, et al. J Invest Dermatol. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

[3] Tejas S Lahoti, et al. Ann Rheum Dis. Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes

Related AhR Products
D-Kynurenine

D-kynurenine is a metabolite of D-tryptophan, which can be used as a biological precursor of KYNA and 3-hydroxykynurenine.

L-Kynurenine

L-Kynurenine is an aryl hydrocarbon receptor agonist.

CAY10465

CAY10465 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor agonist, with a Ki of 0.2 nM.

PDM2

PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM.

YL-109

YL-109 is a novel anticancer agent, which can inhibit breast cancer cell growth and invasiveness in vitro and in vivo, YL-109 is also an STUB1 enhancer.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GNF351 supplier, AhR, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.