Free shipping on all orders over $ 500

CAY10465

Cat. No. M9714
CAY10465 Structure
Synonym:

CAY-10465

Size Price Availability
10mg USD 140 4-7 Days
50mg USD 530 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

CAY10465 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor agonist, with a Ki of 0.2 nM. CAY10465 is inactive as a ligand for the estrogen receptor even at 100 µM. CAY10465 (0.01 nM-100 μM) reduces apolipoprotein A-I (apo A-I) levels in HepG2 cells, and inhibits the synthesis of the protein.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 317.13
Formula C15H9Cl2F3
CAS Number 688348-33-6
Purity >98%
Solubility DMSO ≥ 65 mg/mL
Storage at -20°C
References

Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia
Emad Naem, et al. Life Sci. 2012 Jul 26;91(1-2):64-9. PMID: 22727790.

Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators
Philippe de Medina, et al. J Med Chem. 2005 Jan 13;48(1):287-91. PMID: 15634023.

Related AhR Products
L-Kynurenine

L-Kynurenine is an aryl hydrocarbon receptor agonist.

PDM2

PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM.

YL-109

YL-109 is a novel anticancer agent, which can inhibit breast cancer cell growth and invasiveness in vitro and in vivo.

Perillaldehyde

Perillaldehyde inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.

Diosimin

Diosimin is a flavonoid glycoside found in citrus fruits, hyssop, and rosemary.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CAY10465, CAY-10465 supplier, AhR, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.