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Cat. No. M9714
CAY10465 Structure


Size Price Availability
10mg USD 126  USD140 4-7 Days
50mg USD 477  USD530 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

CAY10465 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor agonist, with a Ki of 0.2 nM. CAY10465 is inactive as a ligand for the estrogen receptor even at 100 µM. CAY10465 (0.01 nM-100 μM) reduces apolipoprotein A-I (apo A-I) levels in HepG2 cells, and inhibits the synthesis of the protein.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 317.13
Formula C15H9Cl2F3
CAS Number 688348-33-6
Purity >98%
Solubility DMSO ≥ 65 mg/mL
Storage at -20°C

Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia
Emad Naem, et al. Life Sci. 2012 Jul 26;91(1-2):64-9. PMID: 22727790.

Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators
Philippe de Medina, et al. J Med Chem. 2005 Jan 13;48(1):287-91. PMID: 15634023.

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Abmole Inhibitor Catalog 2017

Keywords: CAY10465, CAY-10465 supplier, AhR, inhibitors

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