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L-Kynurenine

Cat. No. M9723

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L-Kynurenine Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 60  USD60 In stock
10mg USD 45  USD45 In stock
50mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

L-Kynurenine is an aryl hydrocarbon receptor agonist. L-Kynurenine is a key intermediate in the breakdown of L-tryptophan and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway.

Chemical Information
Molecular Weight 208.21
Formula C10H12N2O3
CAS Number 2922-83-0
Solubility (25°C) DMSO ≥ 10 mg/mL
Water ≥ 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Benjamin J Moyer, et al. Toxicol Appl Pharmacol. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1

[2] Kensuke Sakakibara, et al. J Pharmacol Sci. Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels

[3] J B Pineda-Farias, et al. Eur J Pain. The L-kynurenine-probenecid combination reduces neuropathic pain in rats

[4] K Nozaki, et al. J Cereb Blood Flow Metab. Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats

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Keywords: L-Kynurenine supplier, Aryl hydrocarbon Receptor, inhibitors, activators

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