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L-Kynurenine

Cat. No. M9723
L-Kynurenine Structure
Size Price Availability Quantity
10mg USD 81  USD90 In stock
25mg USD 162  USD180 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

L-Kynurenine is an aryl hydrocarbon receptor agonist. L-Kynurenine is a key intermediate in the breakdown of L-tryptophan and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 208.21
Formula C10H12N2O3
CAS Number 2922-83-0
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1
Benjamin J Moyer, et al. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24. PMID: 27020609.

Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels
Kensuke Sakakibara, et al. J Pharmacol Sci. 2015 Sep;129(1):31-7. PMID: 26318674.

The L-kynurenine-probenecid combination reduces neuropathic pain in rats
J B Pineda-Farias, et al. Eur J Pain. 2013 Oct;17(9):1365-73. PMID: 23529950.

Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats
K Nozaki, et al. J Cereb Blood Flow Metab. 1992 May;12(3):400-7. PMID: 1569135.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: L-Kynurenine supplier, AhR, inhibitors

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