L-Kynurenine is an aryl hydrocarbon receptor agonist. L-Kynurenine is a key intermediate in the breakdown of L-tryptophan and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO ≥ 60 mg/mL|
Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1
Benjamin J Moyer, et al. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24. PMID: 27020609.
Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels
Kensuke Sakakibara, et al. J Pharmacol Sci. 2015 Sep;129(1):31-7. PMID: 26318674.
The L-kynurenine-probenecid combination reduces neuropathic pain in rats
J B Pineda-Farias, et al. Eur J Pain. 2013 Oct;17(9):1365-73. PMID: 23529950.
Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats
K Nozaki, et al. J Cereb Blood Flow Metab. 1992 May;12(3):400-7. PMID: 1569135.
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