Free shipping on all orders over $ 500

Carbidopa monohydrate

Cat. No. M25533
Carbidopa monohydrate Structure
Size Price Availability Quantity
10mg USD 40  USD40 In stock
25mg USD 70  USD70 In stock
50mg USD 95  USD95 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Carbidopa monohydrate is a dopa decarboxylase (DDC) inhibitor, which can be used for the research of Parkinson's disease. Carbidopa monohydrate is also a selective aryl hydrocarbon receptor (AhR) modulator.

Chemical Information
Molecular Weight 244.24
Formula C10H16N2O5
CAS Number 38821-49-7
Solubility (25°C) Soluble in dilute solutions of mineral acids
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] H C Polonini, et al. Pharmazie. Compatibility of cholecalciferol, haloperidol, imipramine hydrochloride, levodopa/carbidopa, lorazepam, minocycline hydrochloride, tacrolimus monohydrate, terbinafine, tramadol hydrochloride and valsartan in SyrSpend SF PH4 oral suspensions

[2] M Bayes, et al. Methods Find Exp Clin Pharmacol. Gateways to Clinical Trials. June 2002

[3] S Vickers, et al. Drug Metab Dispos. Metabolism of carbidopa (1-(-)-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate), an aromatic amino acid decarboxylase inhibitor, in the rat, rhesus monkey, and man

[4] A Scriabine, et al. Clin Sci Mol Med Suppl. Enhancement of the anti-hypertensive effect of methyldopa and other anti-hypertensive drυgs by carbidopa in spontaneously hypertensive rats

[5] S Vickers, et al. J Med Chem. Further studies on the metabolism of carbidopa, (minus)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate, in the human, Rhesus monkey, dog, and rat

Related AhR Products
Benzyl butyl phthalate

Benzyl butyl phthalate can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs).


Indole-3-ylacetaldehyde (I3A)


1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).


β-Naphthoflavone is an aryl hydrocarbon receptor (AhR) agonist, used as a positive control for the induction of AhR transcriptional activity. β-Naphthoflavone inhibits hydrogen peroxide-induced apoptosis.

BAY 2416964

BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. BAY 2416964 has the potential in the treatment of solid tumors.

Abmole Inhibitor Catalog

Keywords: Carbidopa monohydrate supplier, AhR, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.