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FICZ

Cat. No. M9087

All AbMole products are for research use only, cannot be used for human consumption.

FICZ Structure
Synonym:

6-Formylindolo[3,2-b]carbazole

Size Price Availability Quantity
1mg USD 60  USD60 In stock
5mg USD 200  USD200 In stock
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Biological Activity

FICZ is a potent aryl hydrogen receptor (AhR) agonist, with a Kd of 70 pM. FICZ acts by inducing transient expression of cytochrome P450-1A1 (CYP1A1) in vitro. FICZ (10,000-30,000 nM) significantly decreases CEH viability with an estimated LC50 (95% confidence intervals) of 14,000 nM. FICZ shows concentration-dependent effects on EROD activity in CEH cultures, with the mean EC50 values at 3, 8, and 24 h of 0.016 nM, 0.80 nM, and 11 nM, respectively. FICZ treatment increases transcript expression of CYP1A1 in a dose-dependent manner in both the parental iPSC line and the CYP1A1 targeted clone.

Chemical Information
Molecular Weight 284.31
Formula C19H10N2O
CAS Number 172922-91-7
Solubility (25°C) DMSO 10 mg/mL (Need ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mohammadi-Bardbori A, et al. Arch Toxicol. The highly bioactive molecule and signal substance 6-formylindolo[3,2-b]carbazole (FICZ) plays bi-functional roles in cell growth and apoptosis in vitro.

[2] Farmahin R, et al. Biochem Pharmacol. Time-dependent transcriptomic and biochemical responses of 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are explained by AHR activation time.

[3] Wincent E, et al. Biochem Pharmacol. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner.

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Keywords: FICZ, 6-Formylindolo[3,2-b]carbazole supplier, Aryl hydrocarbon Receptor, inhibitors, activators

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