PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO ≥ 45 mg/mL|
Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators
Philippe de Medina, et al. J Med Chem. 2005 Jan 13;48(1):287-91. PMID: 15634023.
Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals
Michael S Denison, et al. Annu Rev Pharmacol Toxicol. 2003;43:309-34. PMID: 12540743.
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