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PDM2

Cat. No. M9693
PDM2 Structure
Synonym:

PDM-2

Size Price Availability Quantity
50mg USD 141.3  USD157 In stock
100mg USD 247.5  USD275 In stock
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Quality Control
Biological Activity

PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 283.58
Formula C14H9Cl3
CAS Number 688348-25-6
Purity 99.71%
Solubility DMSO ≥ 45 mg/mL
Storage at -20°C
References

Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators
Philippe de Medina, et al. J Med Chem. 2005 Jan 13;48(1):287-91. PMID: 15634023.

Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals
Michael S Denison, et al. Annu Rev Pharmacol Toxicol. 2003;43:309-34. PMID: 12540743.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PDM2, PDM-2 supplier, AhR, inhibitors

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