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PDM2

Cat. No. M9693
PDM2 Structure
Synonym:

PDM-2

Size Price Availability Quantity
10mg USD 50  USD50 In stock
50mg USD 157  USD157 In stock
100mg USD 275  USD275 In stock
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Quality Control & Documentation
Biological Activity

PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM.

Chemical Information
Molecular Weight 283.58
Formula C14H9Cl3
CAS Number 688348-25-6
Solubility (25°C) DMSO ≥ 45 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Philippe de Medina, et al. J Med Chem. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators

[2] Michael S Denison, et al. Annu Rev Pharmacol Toxicol. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals

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  Catalog
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Keywords: PDM2, PDM-2 supplier, Aryl hydrocarbon Receptor, inhibitors, activators


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