About 30 results found for searched term "SC-9" (0.002 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1652 | AS703026 | MEK |
| MSC1936369B,Pimasertib | ||
| AS703026 is a novel selective MEK1/2 inhibitor, and induces pleiotropic anti-myeloma activity in vitro and in vivo. | ||
| M1686 | Bortezomib (PS-341) | Proteasome |
| Velcade; PS-341; LDP 341; MG 341; NSC 681239 | ||
| Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM. | ||
| M1782 | NSC 74859 (S3I-201) | STAT |
| S3I-201 | ||
| NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM. NSC 74859 (S3I-201) is effective in hepatocellular cancers with disrupted TGF-beta signaling.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M1807 | SCH727965 (dinaciclib) | CDK |
| Dinaciclib | ||
| SCH727965 (Dinaciclib) is a potent and selective CDK inhibitor with IC50 values of 1, 1, 3 and 4 nM for CDK2, CDK5, CDK1 and CDK9, respectively. | ||
| M1925 | LY294002 | PI3K |
| NSC 697286; SF 1101 | ||
| LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. | ||
| M1970 | Paclitaxel | Microtubule |
| Taxol; NSC 125973 | ||
| Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM. | ||
| M1996 | SCH 900776 | Checkpoint |
| MK-8776 | ||
| SCH 900776 (MK-8776) is a highly potent and functionally selective CHK1 inhibitor with IC50 of 3 nM. | ||
| M2032 | Vicriviroc Malate | CCR |
| SCH 417690 | ||
| Vicriviroc (SCH 417690) is a pyrimidine CCR5 entry inhibitor of HIV-1 with IC50 of 0.91 nM. | ||
| M2057 | Dexrazoxane hydrochloride | Topoisomerase |
| Cardioxane, ICRF-187, NSC169780, Zinecard，DXZ | ||
| Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. | ||
| M2076 | SP600125 | JNK |
| JNK Inhibitor II; 1PMV; NSC75890; Pyrazolanthrone | ||
| SP600125 is a novel and selective inhibitor of c-Jun N-terminal kinase (JNK), inhibited phosphorylation of c-Jun with an IC50 of 5-10 microM. | ||
| M2082 | Streptozotocin | Animal Modeling |
| Streptozocin; STZ; NSC-85998; U 9889 | ||
| Streptozotocin (STZ) is a kind of glucosamine - nitrosourea derivative. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M2084 | SCH772984 | ERK |
| SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. | ||
| M2140 | Posaconazole | Anti-infection |
| SCH 56592; POS | ||
| Posaconazole is a sterol C14α demethylase inhibitor with IC50 of 0.25 nM. | ||
| M2144 | Topotecan hydrochloride | Topoisomerase |
| Hycamtin; NSC 609669; SKF 104864A hydrochloride | ||
| Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. | ||
| M2197 | Sulfasalazine | Ferroptosis |
| Salazopyrin; Azulfidine; Sulphasalazine; SAS; NSC 667219 | ||
| Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer. | ||
| M2217 | Mitoxantrone dihydrochloride | Topoisomerase |
| Mitozantrone dihydrochloride; NSC 301739 dihydrochloride | ||
| Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. | ||
| M2339 | SCH 1473759 | Aurora Kinase |
| SCH1473759 | ||
| SCH 1473759 is a novel subnanometer Aurora A /B inhibitor with IC50 of 4 nM and 13 nM, respectively. | ||
| M2358 | 3-Deazaneplanocin A | Histone Methyltransferase |
| NSC 617989; 3-Deazaneplanocin; DZNep | ||
| 3-deazaneplanocin A (DZNeP), an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM. | ||
| M2378 | Alverine Citrate | 5-HT Receptor |
| NSC 35459 | ||
| Alverine citrate is a compound used for functional gastrointestinal disorders. | ||
| M2541 | CRT0044876 | DNA/RNA Synthesis |
| NSC 69877 | ||
| CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM. | ||
| M2607 | Ametantrone | DNA/RNA Synthesis |
| NSC 196473 | ||
| Ametantrone induces interstrand DNA cross-links in HeLa S3 cells. | ||
| M2705 | Florfenicol | Antibiotic |
| (-)-Florfenicol; SCH-25298 | ||
| Florfenicol is a fluorinated synthetic analog of thiamphenicol with broad-spectrum, primarily bacteriostatic activity. | ||
| M2823 | Loxistatin Acid | Cathepsin |
| E-64C; NSC 694279; EP 475 | ||
| Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. | ||
| M2890 | NSC 632839 | Others |
| F6 | ||
| NSC 632839 is not only a DUB inhibitor, but also a deSUMOylase inhibitor, it inhibits USP2, USP7, and SENP2 with IC50 of 45 μM, 37 μM, and 9.8 μM, respectively. | ||
| M2891 | NSC 319726 | Cuproptosis |
| NSC-319726; ZMC1 | ||
| NSC 319726 is a p53(R175) mutant activator that inhibits the growth of p53(R175) mutant cells and acts on p53(R175) mutant cells with IC50 of 8 nM, which has no inhibition on p53 wild-type cells. NSC 319726 is a potent copper ion-carrier that can be used in cuproptosis studies. | ||
| M2892 | NSC697923 | E1/E2/E3 Enzyme |
| NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. | ||
| M3028 | Spironolactone | Mineralocorticoid Receptor |
| SC9420; Abbolactone | ||
| Spironolactone (SC9420) is an oral active aldosterone mineralocorticoid receptor antagonist with an IC50 value of 24 nM. Spironolactone is also an androgen receptor antagonist with an IC50 of 77 nM. Spironolactone promotes podocyte autophagy. | ||
| M3135 | Zebularine | DNA Methyltransferase |
| NSC309132; 4-Deoxyuridine | ||
| Zebularine is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM. | ||
| M3224 | NSC 207895 | Mdm2 |
| XI-006 | ||
| NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase. | ||
| M3243 | Pyroxamide | HDAC |
| NSC-696085 | ||
| Pyroxamide (NSC 696085) is a potent, affinity-purified HDAC1 inhibitor with ID50 of 100 nM. | ||
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