All AbMole products are for research use only, cannot be used for human consumption.
AG-1478 (Tyrphostin AG-1478) is a highly potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with an IC50 of 3 nM. AG-1478 (Tyrphostin AG-1478) reversibly prevents rat brain Kv1.5 potassium channels (IC50 = 9.8 mM) independent of PTK activity. Additionally, AG-1478 (Tyrphostin AG-1478) also suppresses the growth of leiomyoma and myometrium cell cultures with IC50 values of 5.6 and 5.7 mM, respectively. AG-1478 (Tyrphostin AG-1478) blocke the activation of MAP kinase and strongly represses induction of fos gene expression and DNA synthesis. AG-1478 (Tyrphostin AG-1478) blocks G3 enhanced effects on cell apoptosis.
Aging (Albany NY). 2020 Oct 28;12(20):20801-20816.
Synergistic effect between LH and estrogen in the acceleration of cumulus expansion via GPR30 and EGFR pathways
AG-1478 purchased from AbMole
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Source | Aging (Albany NY) (2020), Figure 5, AG-1478 (AbMole Bioscience, TX, USA) |
| Method | western blot | |
| Cell Lines | cumulus cells | |
| Concentrations | 3 μM | |
| Incubation Time | 8 h | |
| Results | The mRNA of GPR30 was downregulated by EGF stimulation, while AG1478 reversed the inhibition of GPR30 transcription caused by EGF treatment |
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Source | Aging (Albany NY) (2020), Figure 4, AG-1478 (AbMole Bioscience, TX, USA) |
| Method | intraperitoneal injection | |
| Cell Lines | mice | |
| Concentrations | 1 mg/kg body weight | |
| Incubation Time | 1, 3, 5, and 7 day | |
| Results | The results showed that hCG significantly activated p-EGFR (Tyr1068), but AG1478 blocked the activation of p-EGFR induced by hCG stimulation |
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Source | Sci Rep (2018). Figure 4. AG-1478 |
| Method | western blotting | |
| Cell Lines | corneal endothelial cells | |
| Concentrations | 1 μM | |
| Incubation Time | 7 days | |
| Results | The addition of TGF-β1 (with or without AG-1478) also generated the expression of n-cadherin at the cell membrane. The gain of n-cadherin expression following addition of TGF-β1 was confirmed using western blotting |
| Molecular Weight | 315.75 |
| Formula | C16H14ClN3O2 |
| CAS Number | 153436-53-4 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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