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NSC 319726

Cat. No. M2891
NSC 319726 Structure


Size Price Availability Quantity
2mg USD 45  USD45 In stock
5mg USD 58  USD58 In stock
10mg USD 95  USD95 In stock
25mg USD 170  USD170 In stock
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Quality Control & Documentation
Biological Activity

NSC 319726 is a p53(R175) mutant activator that inhibits the growth of p53(R175) mutant cells and acts on p53(R175) mutant cells with IC50 of 8 nM, which has no inhibition on p53 wild-type cells. NSC 319726 is a potent copper ion-carrier that can be used in cuproptosis studies.

Customer Product Validations & Biological Datas
Source Oncotarget (2014). Figure 3. NSC 319726
Method immunoprecipitation
Cell Lines R175H cells
Concentrations 1 μM
Incubation Time 24 h
Results We incubated TOV112D cells with either ZMC1 or NTA and performed immunoprecipitation (IP) experiments with the antibody PAB240, which specifically recognizes misfolded and unfolded p53.
Chemical Information
Molecular Weight 234.32
Formula C11H14N4S
CAS Number 71555-25-4
Solubility (25°C) DMSO 16 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: NSC 319726, NSC-319726 supplier, Cuproptosis, inhibitors, activators

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