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NSC 319726 is a p53(R175) mutant activator that inhibits the growth of p53(R175) mutant cells and acts on p53(R175) mutant cells with IC50 of 8 nM, which has no inhibition on p53 wild-type cells. NSC 319726 is a potent copper ion-carrier that can be used in cuproptosis studies.
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Source | Oncotarget (2014). Figure 3. NSC 319726 |
| Method | immunoprecipitation | |
| Cell Lines | R175H cells | |
| Concentrations | 1 μM | |
| Incubation Time | 24 h | |
| Results | We incubated TOV112D cells with either ZMC1 or NTA and performed immunoprecipitation (IP) experiments with the antibody PAB240, which specifically recognizes misfolded and unfolded p53. |
| Molecular Weight | 234.32 |
| Formula | C11H14N4S |
| CAS Number | 71555-25-4 |
| Solubility (25°C) | DMSO 16 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cuproptosis Products |
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| Cu(II)-Elesclomol
Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol. Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. |
| DL-Penicillamine
DL-Penicillamine is a copper chelating agent. DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response. |
| UM4118
UM4118 is a copper ionophore which can initiate a mitochondrial-based noncanonical form of cell death known as cuproptosis. UM4118 exhibits high sensitivity in SF3B1-mutated and adverse risk acute myeloid leukemia (AML), and can be used for AML research. |
| Ammonium tetrathiomolybdate
Ammonium tetrathiomolybdate is a copper chelator and also is a class of sulfide donor. Ammonium tetrathiomolybdate has neuroprotection effects. Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. |
| 2,2'-Bipyridine
2,2'-Bipyridine has been used in the preparation of copper(II)-bipyridine-naringenin complexes. It can be used for the preparation of 2,2'-bipyridine hydrobromide. 2,2'-Bipyridine has good redox stability and glucose elevating activity. |
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