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NSC 319726

Cat. No. M2891
NSC 319726 Structure
Synonym:

NSC-319726

Size Price Availability Quantity
2mg USD 45  USD45 In stock
5mg USD 58  USD58 In stock
10mg USD 95  USD95 In stock
25mg USD 170  USD170 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

NSC 319726 is a p53(R175) mutant activator that inhibits the growth of cells expressing mutant p53. It acts on p53(R175) mutant with IC50 of 8 nM and has no inhibition on p53 wild-type cells. It is a powerful copper ion-carrier and can be used for the study of copper death.

Customer Product Validations & Biological Datas
Source Oncotarget (2014). Figure 3. NSC 319726
Method immunoprecipitation
Cell Lines R175H cells
Concentrations 1 μM
Incubation Time 24 h
Results We incubated TOV112D cells with either ZMC1 or NTA and performed immunoprecipitation (IP) experiments with the antibody PAB240, which specifically recognizes misfolded and unfolded p53.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 234.32
Formula C11H14N4S
CAS Number 71555-25-4
Purity >98%
Solubility DMSO 16 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




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