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3-Deazaneplanocin-A, a carbocyclic analog of adenosine, was synthesized as an inhibitor of -adenosylhomocysteine hydrolase. 3-Deazaneplanocin-A treatment induced apoptosis in cultured and primary AML cells. In addition, 3-Deazaneplanocin A depletes EZH2 levels, and inhibits trimethylation of lysine 27 on histone H3 in the HL-60 and OCI-AML3 cells and in primary AML cells. 3-Deazaneplanocin A treatment induces p16, p21, p27, and FBXO32 while depleting cyclin E and HOXA9 levels.
Biochem Pharmacol. 2022 Oct 31;206:115334.
MCP-1 facilitates VEGF production by removing miR-374b-5p blocking of VEGF mRNA translation
3-Deazaneplanocin A purchased from AbMole
| Molecular Weight | 262.26 |
| Formula | C12H14N4O3 |
| CAS Number | 102052-95-9 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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