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SCH 1473759

Cat. No. M2339
SCH 1473759 Structure
Synonym:

SCH1473759

Size Price Availability
5mg USD 270  USD270 Custom Synthesis
10mg USD 390  USD390 Custom Synthesis
50mg USD 990  USD990 Custom Synthesis
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SCH 1473759 is a novel subnanometer Aurora A /B inhibitor with IC50 of 4 nM and 13 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 426.54
Formula C20H26N8OS
CAS Number 1094069-99-4
Purity >98%
Solubility DMSO
Storage at -20°C
References

[1] Basso AD, et al. Cancer Chemother Pharmacol. SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors.

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  Catalog
Abmole Inhibitor Catalog




Keywords: SCH 1473759, SCH1473759 supplier, Aurora Kinase, inhibitors

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