| Cat.No. | Name | Information |
|---|---|---|
| M1881 | Tozasertib | Tozasertib (VX-680, MK-0457) is a potent and selective pan-Aurora kinase inhibitor active against all Bcr/Abl proteins. |
| M1752 | Aliertib (MLN 8237) | Alisertib (MLN8237) is a second-generation, orally bioavailable, highly selective Aurora kinase A inhibitor with IC50 of 61 nM. |
| M1663 | AZD1152-HQPA | AZD1152-HQPA (Barasertib) is a highly potent and selective inhibitor of Aurora with Ki values of 0.36 and 1369 nM for Aurora B and Aurora A respectively. |
| M21755 | Barasertib | Barasertib (AZD1152), a precursor of Barasertib-hQPA, is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay. Barasertib (AZD1152) induces growth arrest and apoptosis in cancer cells. |
| M13592 | ENMD-2076 Tartrate | ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively. |
| M9895 | LY3295668 | LY3295668 (AK-01) is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. |
| M7537 | SNS-314 | SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. |
| M3931 | Aurora Kinase Inhibitor III | Aurora Kinase Inhibitor III is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM. |
| M3701 | SNS-314 Mesylate | SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. |
| M3555 | GSK1070916 | GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. |
| M3552 | PHA-680632 | PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3. |
| M3516 | MK-5108 | MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. |
| M2856 | MK-8745 | MK-8745 is a potent and selective Aurora A inhibitor with IC50 of 0.6 nM, more than 450-fold selectivity for Aurora A over Aurora B. |
| M2364 | ABT-348 | ABT-348 is a novel ATP-competitive inhibitor of Aurora B, Aurora C and Aurora A with IC50 of 7 nM, 1 nM and 120 nM, respectively. |
| M2339 | SCH 1473759 | SCH 1473759 is a novel subnanometer Aurora A /B inhibitor with IC50 of 4 nM and 13 nM, respectively. |
| M2188 | Reversine | Reversine is a novel small molecule ATP-competitive Aurora kinase inhibitor with IC50 of 98.5 nM for Aurora B. |
| M2169 | AMG 900 | AMG 900 is a potent and selective, orally available small molecule aurora kinase inhibitor. |
| M2154 | TAK-901 | TAK-901 is a novel small-molecule inhibitor of Aurora A and Aurora B with IC50 of 21 nM and 15 nM. |
| M2127 | Hesperadin | Hesperadin is an ATP-competitive inhibitor of Aurora B kinase with IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. |
| M2103 | CCT137690 | CCT137690 is a potent inhibitor of Aurora kinases with IC50 values of 15, 19 and 25 nM at Aurora A, Aurora C and Aurora B respectively. |
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