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Aurora Kinase Aurora Kinase

Inhibitors

Cat.No.  Name Information
M1881 Tozasertib Tozasertib (VX-680, MK-0457) is a potent and selective pan-Aurora kinase inhibitor active against all Bcr/Abl proteins.
M1752 MLN8237 (Alisertib) MLN8237 (Alisertib) is a second-generation, orally bioavailable, highly selective Aurora kinase A inhibitor with IC50 of 61 nM.
M1663 AZD1152-HQPA AZD1152-HQPA (Barasertib) is a highly potent and selective inhibitor of Aurora with Ki values of 0.36 and 1369 nM for Aurora B and Aurora A respectively.
M20733 SP-96 SP-146 is a potent, selective and non-ATP-competitive inhibitor of Aurora B with IC50 of 0.316 nM. SP-146 can be used for the research of triple negative breast cancer (TNBC).
M20284 WAY-661516 WAY-661516 is a Aurora kinase A inhibitor.
M20251 WAY-638641 WAY-638641 is a Aurora kinase A inhibitor.
M20247 WAY-636982 WAY-636982 is a Aurora kinase A inhibitor.
M20246 WAY-636900 WAY-636900 is a Aurora kinase A inhibitor.
M20245 WAY-635767 WAY-635767 is a Aurora kinase A inhibitor
M20244 WAY-635764 WAY-635764 is a Aurora kinase A inhibitor.
M20238 WAY-634704 WAY-634704 is a Aurora kinase A inhibitor.
M20235 WAY-632963 WAY-632963 is a Aurora kinase A inhibitor.
M20066 WAY-298668 WAY-298668 altering the lifespan of a eukaryotic organism
M13592 ENMD-2076 Tartrate ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.
M13591 Cenisertib Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3.
M9895 LY3295668 LY3295668 (AK-01) is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.
M7537 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2.
M3931 Aurora Kinase Inhibitor III Aurora Kinase Inhibitor III is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM.
M3701 SNS-314 Mesylate SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively.
M3555 GSK1070916 GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex.
M3552 PHA-680632 PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.
M3516 MK-5108 MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity.
M3221 PF-03814735 PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1.



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