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Aurora Kinase Inhibitor III

Cat. No. M3931
Aurora Kinase Inhibitor III Structure
Synonym:

Aurora Kinase Inhibitor 3

Size Price Availability Quantity
1mg USD 90  USD90 In stock
2mg USD 155  USD155 In stock
5mg USD 350  USD350 In stock
10mg USD 550  USD550 In stock
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Quality Control
Biological Activity

Aurora Kinase Inhibitor III also weakly inhibits EGFR with an IC50>10 μM. Aurora Kinase Inhibitor III has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 413.40
Formula C21H18F3N5O
CAS Number 879127-16-9
Purity 99.58%
Solubility DMSO ≥15 mg/mL (May need ultrasonic)
Storage at -20°C
References

[1] Tari LW, et al. Bioorg Med Chem Lett. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors.

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Keywords: Aurora Kinase Inhibitor III, Aurora Kinase Inhibitor 3 supplier, Aurora Kinase, inhibitors

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