About 25 results found for searched term "SC 66" (0.059 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2100 | Bleomycin sulfate | Animal Modeling |
| Blenoxane; NSC125066; BLEO | ||
| Bleomycin sulfate (Blenoxane) is a glycopeptide antitumor antibiotic isolated from Streptomyces verticillus. | ||
| M2144 | Topotecan hydrochloride | Topoisomerase |
| Hycamtin; NSC 609669; SKF 104864A hydrochloride | ||
| Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. | ||
| M2197 | Sulfasalazine | Ferroptosis |
| Salazopyrin; Azulfidine; Sulphasalazine; SAS; NSC 667219 | ||
| Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer. | ||
| M2207 | NSC 66811 | Mdm2 |
| NSC 66811 is a potent MDM2 inhibitor with Ki value of 120 nM, which disrupts MDM2-p53 interaction and activates p53 function. | ||
| M2307 | Lonafarnib | Transferase |
| SCH66336 | ||
| Lonafarnib (SCH 66336) is a selectively FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. | ||
| M2889 | NSC23766 trihydrochloride | GTPase |
| NSC23766 3HCl salt | ||
| NSC23766 3HCl is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA. | ||
| M3173 | Potassium canrenoate | Mineralocorticoid Receptor |
| Aldadiene potassium, SC-14266 | ||
| Canrenoate potassium is a predrug for the release of Canrenone and an effective antagonist of competitive salt ocorticoid receptor. As a diuretic, Canrenoate potassium is used in the study of hypertension. | ||
| M3403 | PNU-120596 | AChR/AChE |
| Nsc 216666 | ||
| PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM. | ||
| M3774 | Kenpaullone | CDK |
| NSC-664704, 9-Bromopaullone, 9-Bromo-7 | ||
| Kenpaullone is potent inhibitor of CDK1/cyclin B and GSK-3β with IC50 values of 0.4 and 0.23 μM respectively. | ||
| M5835 | Ondansetron Hydrochloride Dihydrate | 5-HT Receptor |
| GR 38032; SN 307; NSC 665799 | ||
| Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist (Ki=6.16 nM), with low affinity for dopamine receptors. | ||
| M6282 | NSC 23766 | Ras |
| NSC23766 | ||
| NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA. | ||
| M6332 | 3-AP | DNA/RNA Synthesis |
| 3-AP; PAN-811; OCX191; NSC663249 | ||
| 3-AP is a ribonucleotide reductase inhibitor; also an iron chelator. | ||
| M6558 | Canrenone | Mineralocorticoid Receptor |
| Aldadiene; SC9376; SC14266 | ||
| Canrenone is a mineralocorticoid receptor antagonist. | ||
| M7057 | NSC 663284 | Others |
| DA-3003-1 | ||
| NSC 663284 is a potent, selective Cdc25 phosphatase inhibitor. | ||
| M7058 | NSC 668036 | Others |
| NSC 668036 is a wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) protein. | ||
| M7276 | SC 66 | Others |
| SC 66 is a allosteric Akt inhibitor. | ||
| M7911 | Merbarone | Topoisomerase |
| NSC 336628 | ||
| Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. | ||
| M8728 | ESI-05 | Transferase |
| NSC 116966 | ||
| Esi-05 (NSC 116966) is a camp-specific direct activated exchange protein 2 (EPAC2) antagonist with an IC50 value of 0.4 µM that inhibits camp-induced EPAC2 activation and EAPC2-mediated Rap1 activation. | ||
| M11039 | Pyrazoloacridine | Topoisomerase |
| NSC 366140 | ||
| Pyrazoloacridine (NSC 366140) has anticancer activity, inhibiting the activity of topoisomerases 1 and 2 (topoisomerases 1 and 2). Pyrazoloacridine (NSC 366140) on K562 in myeloid leukemia cells IC50 The value is 1.25 μM (24 h). | ||
| M14747 | NSC668394 | Others |
| NSC668394 is a potent ezrin (Thr567) phosphorylation inhibitor, with a Kd of 12.59 μM. | ||
| M27812 | Ecopipam | Dopamine Receptor |
| SCH 39166 | ||
| Ecopipam (SCH 39166) is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam can be used for the research of schizophrenia and obesity. | ||
| M29005 | Ecopipam hydrochloride | Dopamine Receptor |
| SCH 39166 hydrochloride | ||
| Ecopipam (SCH 39166) hydrochloride is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrochloride shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrochloride can be used for the research of schizophrenia and obesity. | ||
| M29720 | Ecopipam hydrobromide | Dopamine Receptor |
| SCH 39166 hydrobromide | ||
| Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity. | ||
| M42506 | SCAL-266 | Mitochondrial Related |
| SCAL-266 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 0.83 μM. | ||
| M49366 | Boc-Glycine | Others |
| N-tert-Butoxycarbonyl-2-aminoacetic acid; NSC 127669 | ||
| Boc-Glycine is a glycine derivative that can be used in peptide synthesis. | ||
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