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NSC23766 trihydrochloride

Cat. No. M2889
NSC23766 trihydrochloride Structure
Synonym:

NSC23766 3HCl salt

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 60  USD60 In stock
10mg USD 105  USD105 In stock
50mg USD 440  USD440 In stock
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Quality Control
Biological Activity

NSC23766 3HCl is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA.

Product Citations
Customer Product Validations & Biological Datas
Source bioRxiv 2021. Figure 1. NSC23766 (Abmole Bioscience, USA)
Method Immunofluorescence
Cell Lines Hela human cervical carcinoma cell、Madin-Darby canine kidney (MDCK) cells、 MDA-MB-231 human breast cancer cell、U2OS human osteosarcoma cell
Concentrations 20 µM
Incubation Time 48 hours
Results Progressive compression gradient is strengthened in epidermal layer during chicken feather follicle morphogenesis
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 530.96
Formula C24H35N7.3HCl
CAS Number 1177865-17-6
Purity 99.76%
Solubility Water: ≥ 25 mg/mL
Storage at -20°C
References

[1] Rajakrishnan Veluthakal, et al. Cell Physiol Biochem. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model

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Keywords: NSC23766 trihydrochloride, NSC23766 3HCl salt supplier, GTPase, inhibitors

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