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NSC23766 3HCl is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA.
bioRxiv. 2021 Apr 26.
Self-organization of Tissue Growth by Interfacial Mechanical Interactions in Multi-layered Systems
NSC23766 trihydrochloride purchased from AbMole
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Source | bioRxiv 2021. Figure 1. NSC23766 (Abmole Bioscience, USA) |
| Method | Immunofluorescence | |
| Cell Lines | Hela human cervical carcinoma cell、Madin-Darby canine kidney (MDCK) cells、 MDA-MB-231 human breast cancer cell、U2OS human osteosarcoma cell | |
| Concentrations | 20 µM | |
| Incubation Time | 48 hours | |
| Results | Progressive compression gradient is strengthened in epidermal layer during chicken feather follicle morphogenesis |
| Molecular Weight | 530.96 |
| Formula | C24H35N7.3HCl |
| CAS Number | 1177865-17-6 |
| Solubility (25°C) | Water: ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related GTPase Products |
|---|
| Nexinhib20
Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 µM). |
| EHop-016
EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1, equally potent inhibition for Rac3. |
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