NSC23766 3HCl is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA.
bioRxiv. 2021 Apr 26.
Self-organization of Tissue Growth by Interfacial Mechanical Interactions in Multi-layered Systems
NSC23766 trihydrochloride purchased from AbMole
|Source||bioRxiv 2021. Figure 1. NSC23766 (Abmole Bioscience, USA)|
|Cell Lines||Hela human cervical carcinoma cell、Madin-Darby canine kidney (MDCK) cells、 MDA-MB-231 human breast cancer cell、U2OS human osteosarcoma cell|
|Incubation Time||48 hours|
|Results||Progressive compression gradient is strengthened in epidermal layer during chicken feather follicle morphogenesis|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||Water: ≥ 25 mg/mL|
|Related GTPase Products|
EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1, equally potent inhibition for Rac3.
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