About 30 results found for searched term "GTPase" (0.131 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2562 | ZCL278 | Ras |
| ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. | ||
| M2569 | Dynasore | Dynamin |
| Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM. | ||
| M2663 | EHop-016 | GTPase |
| EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1, equally potent inhibition for Rac3. | ||
| M2830 | Mdivi-1 | Dynamin |
| Mitochondrial division inhibitor 1 | ||
| Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. | ||
| M2889 | NSC23766 trihydrochloride | GTPase |
| NSC23766 3HCl salt | ||
| NSC23766 3HCl is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA. | ||
| M5481 | CASIN | Ras |
| CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM. | ||
| M6188 | QS11 | Others |
| QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. | ||
| M6282 | NSC 23766 | Ras |
| NSC23766 | ||
| NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA. | ||
| M6704 | EHT 1864 2HCl | Ras |
| EHT1864 | ||
| EHT 1864 is a potent inhibitor of Rac family GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. | ||
| M6968 | ML141 (CID-2950007) | Ras |
| CID-2950007 | ||
| ML141 (CID-2950007) is a selective inhibitor of Cdc42 Rho family GTPase. | ||
| M7186 | RBC8 | Others |
| RBC8 is a ralA and RalB GTPase inhibitor. | ||
| M7194 | Rhosin hydrochloride | Ras |
| G04 hydrochloride | ||
| Rhosin hydrochloride is a rho GTPase inhibitor. | ||
| M7791 | Exo-1 | Others |
| Exo1 | ||
| Exo1 is a reversible inhibitor of exocytosis, also a Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator. | ||
| M8415 | CID44216842 | Others |
| CID44216842 is a potent and selective non-competitive allosteric inhibitor of Cdc42 GTPase that does not inhabit Rho and Rac. | ||
| M8483 | ML099 | Others |
| ML099 is a Ras-related GTPase activator. | ||
| M8601 | R-Ketorolac | Others |
| R-Ketorolac is potent and selective Rho-family GTPases Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) allosteric inhibitor that modulates downstream GTPase-dependent physiologic responses critical to tumor metastasis. | ||
| M9817 | MLS000532223 | Ras |
| MLS000532223 is a selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM. | ||
| M10268 | CID-1067700 (ML282) | Ras |
| CID-1067700 | ||
| CID-1067700 (ML282) is a competitive inhibitors of nucleotide binding by Ras-related GTPases with a Ki of 13 nM for Rab7. | ||
| M20607 | BQU57 | ROCK |
| BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. | ||
| M21080 | AZD4625 | Ras |
| AZD4625 is a highly potent, selective, covalent and metabotropic inhibitor of the mutant GTPase KRASG12C. AZD4625 has high oral bioavailability. It is being developed to study advanced solid malignancies. | ||
| M21687 | Nexinhib20 | GTPase |
| Rab27 Inhibitor | ||
| Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 µM). | ||
| M27824 | Dynole 34-2 | Dynamin |
| Dynole 34-2 is a dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME). | ||
| M27882 | Rhosin | Ras |
| Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin induces cell apoptosis. Rhosin promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability. | ||
| M29945 | Bragsin2 | Others |
| Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells. | ||
| M30401 | 8-CPT-2Me-cAMP sodium | Ras |
| 8-CPT-2Me-cAMP sodium is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50> 10 μM). 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro. | ||
| M41054 | FtsZ-IN-5 | Antibiotic |
| FtsZ-IN-5 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. | ||
| M41055 | FtsZ-IN-6 | Antibiotic |
| FtsZ-IN-6 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. | ||
| M41056 | FtsZ-IN-7 | Antibiotic |
| FtsZ-IN-7 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. | ||
| M41057 | FtsZ-IN-8 | Antibiotic |
| FtsZ-IN-8 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. | ||
| M49367 | SML-8-73-1 | Ras |
| SML-8-73-1 is a GDP analog and also a KRAS inhibitor that irreversibly covalently binds to the GTPase active site of KRAS, and its binding rate to KRAS G12C was more than 95% in a 1 mmol/L GDP/GTP environment, and the IC 50 value for the inhibition of the proliferation of lung cancer cells H358 was 26.6 μmol/L . | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
