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Pyrazoloacridine

Cat. No. M11039

All AbMole products are for research use only, cannot be used for human consumption.

Pyrazoloacridine Structure
Synonym:

NSC 366140

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Quality Control & Documentation
Biological Activity

Pyrazoloacridine (NSC 366140) has anticancer activity, inhibiting the activity of topoisomerases 1 and 2 (topoisomerases 1 and 2). Pyrazoloacridine (NSC 366140) on K562 in myeloid leukemia cells IC50 The value is 1.25 μM (24 h).

Chemical Information
Molecular Weight 367.4
Formula C19H21N5O3
CAS Number 99009-20-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Bhuvaneswari Ramaswamy, et al. Invest New Drugs. Phase II trial of pyrazoloacridine (NSC#366140) in patients with metastatic breast cancer

[2] Evanthia Galanis, et al. Invest New Drugs. Phase I/II trial of pyrazoloacridine and carboplatin in patients with recurrent glioma: a North Central Cancer Treatment Group trial

[3] Nino Keshelava, et al. Clin Cancer Res. Pyrazoloacridine is active in multidrug-resistant neuroblastoma cell lines with nonfunctional p53

[4] J Vuky, et al. Invest New Drugs. Phase II trial of pyrazoloacridine in patients with cisplatin-refractory germ cell tumors

[5] A A Adjei. Invest New Drugs. Current status of pyrazoloacridine as an anticancer agent

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Keywords: Pyrazoloacridine, NSC 366140 supplier, Topoisomerase, inhibitors, activators

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