About 26 results found for searched term "Pyr10" (0.136 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9180 | Pyridostatin Trifluoroacetate Salt | DNA/RNA Synthesis |
| Pyridostatin TFA salt; PDS; CAS# 1085412-37-8(free base) | ||
| Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer, with a Kd of 490 nM. | ||
| M14285 | Pyr10 | TRP Channel |
| Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. | ||
| M17949 | 3-(β-D-Glucopyranosyloxy)-1,6-dihydroxy-2-methyl-9,10-anthracenedione | Others |
| 3-（β-D-Glucopyranosyloxy）-1,6-dihydroxy-2-methyl-9,10-anthracenedione | ||
| M53136 | (Des-Pyr1, Des-Gly10, D-Leu6, Pro-NHEt9)-LHRH | LHRH/GnRH |
| (Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. | ||
| M1692 | CHIR-99021 | GSK-3 |
| CT99021; Laduviglusib | ||
| CHIR-99021 (CT99021) is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. | ||
| M1755 | WYE-354 | mTOR |
| WYE-354 is a cell-permeable pyrazolopyrimidine compound that acts as a potent and ATP-competitive mTOR inhibitor (IC50 = 5 nM with S6K as the substrate and 100 µM ATP). | ||
| M2760 | Hydroxyzine dihydrochloride | Histamine Receptor |
| Hydroxyzine is a histamine H1-receptor antagonist, inhibits binding of [3H]pyrilamine/[3H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM. | ||
| M3243 | Pyroxamide | HDAC |
| NSC-696085 | ||
| Pyroxamide (NSC 696085) is a potent, affinity-purified HDAC1 inhibitor with ID50 of 100 nM. | ||
| M3462 | Nisoldipine | Calcium Channel |
| BAY-k 5552 | ||
| Nisoldipine (Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM. | ||
| M3946 | BML-275 | AMPK |
| Dorsomorphin, Compound C | ||
| BML-275 (Dorsomorphin) is a cell-permeable pyrazolopyrimidine compound shown to be an AMPK inhibitor with Ki of 109 nM in cell-free assays. | ||
| M5441 | Bacitracin Zinc | Antibiotic |
| Bacitracin zinc salt; Zinc bacitracin | ||
| Bacitracin Zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM. | ||
| M8622 | TVB-3166 | FAS |
| TVB3166 | ||
| TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p. | ||
| M8723 | PBOX-15 | Others |
| PBOX-15 belongs to a group of tubulin-targeting pyrrolo-1,5-benzoxazepine (PBOX) compounds that potently induce apoptosis in a wide spectrum of cancer cells, including those originating from the four main types of leukemia and those exhibiting multi-drug resistance (IC50 = 155 nM/HL60-MDR1, 252 nM/HL60-ABCG2, 210 nM/HL60). | ||
| M9095 | Marinopyrrole A | Bcl-2 |
| Maritoclax; (±)-Marinopyrrole | ||
| Marinopyrrole A (Maritoclax) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM. | ||
| M11003 | Benpyrine | Others |
| Benpyrine is a highly specific orally active TNF-α inhibitor.KD The value is 82.1 μM. Benpyrine binds tightly to TNF-α and blocks its interaction with TNFR1,IC50 The value is 0.109 μM. | ||
| M27941 | AV-105 | Others |
| AV-105 is a Florbetapir (18F)-radiolabeled slyrylpyridine tosylate precursor extracted from patent WO2010078370A1, example 1.5. AV-105 can synthesize 18F-radiolabeled compounds, which are used for positron emission tomography (PET) imaging of neurodegenerative diseases of the brain. | ||
| M28081 | Intoplicine | Topoisomerase |
| RP 60475 | ||
| Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA. | ||
| M28197 | Intoplicine dimesylate | Topoisomerase |
| RP 60475 dimesylate | ||
| Intoplicine (RP 60475) dimesylate, an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine dimesylate strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA. | ||
| M28598 | PYD-106 | GluR |
| PYD-106 is a stereoselective pyrrolidinone (PYD) positive allosteric modulator for GluN2C-containing NMDA receptors. PYD-106 increases opening frequency and open time of single channel currents activated by maximally effective concentrations of agonist but only has modest effects on glutamate and glycine EC50. PYD-106 selectively enhances the responses of diheteromeric GluN1/GluN2C receptors but not triheteromeric GluN1/GluN2A/GluN2C receptors. | ||
| M28803 | Triptonine B | HIV Protease |
| Triptonine B, a sesquiterpene pyridine alkaloid, inhibits HIV replication in H9 lymphocytes with an EC50 value of <0.10 μg/mL. | ||
| M28944 | FF-10502 | Nucleoside Antimetabolite/Analog |
| FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells. | ||
| M29035 | KIRA-7 | IRE1 |
| KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect. | ||
| M29610 | NBD-14270 | HIV Protease |
| NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses. NBD-14270 binds to HIV-1 gp120 and shows potent antiviral activity. NBD-14270 shows low cytotoxicity (CC50>100 μM). | ||
| M30952 | Lck inhibitor 2 | Src-bcr-Abl |
| Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively IC50 Value: 13 nM(Lck) [1] Target: Src family kinase Lck inhibitor 2(Compound 9) inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM). | ||
| M40059 | Pyrenophorol | Others |
| Pyrenophorol is a C9H12O3 compound isolated in low yield from culture filtrates of the phytopathogenic fungus Stemphylium radicinum, C.M.I. 105654. | ||
| M42178 | 1-Phenyl-2-pyrrolidinone | GABA Receptor |
| 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a phenyl analogue of GABA with sedative effect, decreasing the exploratory behavior of rats at 50-100 mg/kg (i.v.). | ||
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