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NBD-14270 

Cat. No. M29610

All AbMole products are for research use only, cannot be used for human consumption.

NBD-14270  Structure

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Quality Control & Documentation
Biological Activity

NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses. NBD-14270 binds to HIV-1 gp120 and shows potent antiviral activity. NBD-14270 shows low cytotoxicity (CC50>100 μM).

Chemical Information
Molecular Weight 425.43
Formula C18H18F3N5O2S
CAS Number 2411819-82-2
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage 4°C, protect from light, dry, sealed
References

[1] Alexander V Kurkin, et al. ChemMedChem. Design, Synthesis, and Antiviral Activity of the Thiazole Positional Isomers of a Potent HIV-1 Entry Inhibitor NBD-14270

[2] Natalie Losada, et al. J Med Chem. HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites

[3] Francesca Curreli, et al. J Med Chem. Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation

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Keywords: NBD-14270  supplier, HIV Protease, inhibitors, activators

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