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Intoplicine (RP 60475) dimesylate, an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine dimesylate strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA.
| Molecular Weight | 540.65 |
| Formula | C23H32N4O7S2 |
| CAS Number | 133711-99-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 115 mg/mL (ultrasonic) Water 100 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light, dry, sealed |
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