Certificate of Analysis
| Product Name: | Intoplicine dimesylate |
| Catalog Number: | M28197 |
| CAS Number: | 133711-99-6 |
Physical and Chemical Properties
| Formula: | C23H32N4O7S2 |
| Molecular Weight: | 540.65 |
| Form: | Solid |
| Solubility: | DMSO 115 mg/mL (ultrasonic); Water 100 mg/mL (ultrasonic) |
| Storage: | 4°C, protect from light, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Intoplicine (RP 60475) dimesylate, an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine dimesylate strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |