All AbMole products are for research use only, cannot be used for human consumption.
Nisoldipine (Sular) is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, it relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload . [1, 2]
| Cell Experiment | |
|---|---|
| Cell lines | Ventricular myocytes |
| Preparation method | Bathing the myocytes in normal Tyrode's solution, held at -80 mV, and depolarised after 200-ms prepulses (-40mV) to more positive potentials for 500 ms at 0.1 Hz, recording tail currents on repolarisations to -40mV. Exposing the myocytes to 10-100 mM Nisoldipine for 8-10 minutes. Then using an EPC-7 amplifier to record the whole-cell membrane currents. |
| Concentrations | Dissolved in DMSO, final concentration 10-100 μM |
| Incubation time | 8-10 minutes |
| Animal Experiment | |
|---|---|
| Animal models | Male Wistar rats with chronic intragastric ethanol exposure |
| Formulation | Dissolved in DMSO and diluted in saline |
| Dosages | 10 mg/kg |
| Administration | Oral every day |
| Molecular Weight | 388.41 |
| Formula | C20H24N2O6 |
| CAS Number | 63675-72-9 |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] R Heinig. Clinical pharmacokinetics of nisoldipine coat-core
[3] J Langan, et al. Nisoldipine CC: clinical experience in hypertension
| Related Calcium Channel Products |
|---|
| CBD3063
CBD3063 is a selective, first-in-class, CRMP2-based peptidomimetic small molecule, which allosterically regulates Cav2.2 to achieve analgesia and pain relief without negative side effect profiles. |
| TTA-A8
TTA-A8 is a short-acting T-type calcium channel antagonist with oral activity, exhibiting an IC50 value of 31.3 nM in the FLIPR depolarization assay. |
| MONIRO-1
MONIRO-1 is a T-type and N-type calcium channel blocker with IC50 values of 34, 3.3, 1.7 and 7.2 µM against hCav2.2, hCav3.1, hCav3.2 and hCav3.3, respectively. |
| Azumolene
Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. |
| Nexopamil
Nexopamil is a calcium antagonist of Ca2+ channel, 5HT2, 5HT1A, 5HT1C and dopamine D2 receptors. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
