About 31 results found for searched term "PORT-8" (0.148 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M40650 | PORT-8 | Adenosine Receptor |
| TT-53 | ||
| PORT-8 is a dual inhibitor of adenosine receptors A2aR and A2bR and can be used in studies related to solid tumors. | ||
| M2445 | Benztropine mesylate | Dopamine Receptor |
| Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate | ||
| Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM. Benztropine mesylate is a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects. Benztropine mesylate is also an anti-histamine agent and a dopamine re-uptake inhibitor. | ||
| M2624 | Desvenlafaxine Succinate | 5-HT Receptor |
| O-Desmethylvenlafaxine succinate hydrate | ||
| Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively. | ||
| M4597 | Silicristin | Monocarboxylate Transporter (MCT) |
| Silychristin is a flavonoid rich in milk thistle fruits, which has antioxidant effects. Silychristin is an effective inhibitor of thyroid hormone transporter MCT8 and can strongly inhibit T3 uptake with IC50 of 110 nM. | ||
| M5464 | Bitopertin | GlyT |
| RG1678, RO-4917838 | ||
| Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells. | ||
| M5734 | Lesinurad | URAT1 |
| RDEA 594, RDEA-594, RDEA594 | ||
| Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively. | ||
| M6255 | JPH203 | Autophagy |
| KYT-0353 | ||
| JPH203, a selective L-type amino acid transporter 1 (LAT1) inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells. | ||
| M6664 | Desipramine hydrochloride | Dopamine Receptor |
| Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively. | ||
| M8623 | RSV604 (A-60444) | RSV |
| A-60444; RSV-604 | ||
| RSV604 (A-60444) is a cell-permeable, non-cytotoxic (CC50 >50 μM) benzodiazepine derivative that is reported to target respiratory syncytial virus (RSV) nucleoprotein (N), with a Kd of 1.6 μM. RSV604 displays submicromolar activity against numerous clinical isolates of both the A and B subtypes of RSV (average EC50s=0.8 μM). | ||
| M8659 | BAY-876 | GLUT |
| BAY-876 is a potent, highly selective, cell-permeable inhibitor of glucose transporter GLUT1 with an IC50 of 2 nM. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis. | ||
| M8835 | UA62784 | Others |
| Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor. | ||
| M8836 | U18666A | Anti-infection |
| U 18666A | ||
| U18666A is an intra-cellular cholesterol transport inhibitor. U18666A inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus. | ||
| M9115 | PF-06869206 | Sodium Channel |
| PF06869206; PF-6869206 | ||
| PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM. | ||
| M9510 | JWG-071 | ERK |
| JWG-071 is the first reported kinase-selective chemical probe for ERK5, inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively. | ||
| M10815 | Elobixibat | Others |
| A 3309 | ||
| Elobixibat is a potent ileal bile acid transporter (IBAT) inhibitor, IC50 Values were 0.53±0.17 nM (human IBAT), 0.13±0.03 nM (mouse IBAT), 5.8± 1.6 nM (canine IBAT). | ||
| M11481 | Abatacept | Fusion Proteins |
| Orencia；CTLA4lg；BMS-188667 | ||
| Abatacept is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1. Abatacept binds to antigen presenting cells CD80 and CD86, blocks costimulatory signals and inhibits T cell activation, and is used in the study of rheumatoid arthritis and juvenile rheumatoid arthritis. | ||
| M11485 | Recombinant Mouse GM-CSF Protein (E. coli) | Cytokines and Growth Factors |
| Granulocyte Macrophage Colony Stimulating Factor; CSF-2; MGI-1GM | ||
| Recombinant GM-CSF Protein is a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. GM-CSF is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to cytokine of immune and inflammatory. ED50 < 5.0 pg/ mL, measured in cell proliferation assay of mouse FDC-P1 cells, corresponding specific activity > 2.0 × 108 units/mg. | ||
| M11515 | Hoechst 34580 | Fluorescent Dye |
| HOE 34580 | ||
| Hoechst 34580 (HOE 34580) is related to important small furrow binding dsDNA selective dyes Hoechst 33258 and Hoechst 33342, with a maximum excitation/emission wavelength of 392nm/440 nm (after binding to DNA), emitting blue fluorescence. For observation of nuclei, nucleic acids, stored at -25°C, away from light. | ||
| M15042 | Recombinant Human Adiponectin (CHO) | Cytokines and Growth Factors |
| Acrp-30; GBP-28; Apm-1 | ||
| Adiponectin is an important adipocytokine involved in the control of fat metabolism and insulin sensitivity. It is made only by fat cells and secreted into plasma. Protein structure: Acrp30 (GLU19-ASN244), Accession # : Q15848. | ||
| M15043 | Recombinant Human Adiponectin/Acrp30 (HEK 293) | Cytokines and Growth Factors |
| Acrp-30; GBP-28; Apm-1 | ||
| Adiponectin is an important adipocytokine involved in the control of fat metabolism and insulin sensitivity. It is made only by fat cells and secreted into plasma. Protein structure: Acrp30 (Lys101-ASN244), Accession # ：Q15848. | ||
| M14237 | BAY-8002 | Monocarboxylate Transporter (MCT) |
| BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity. | ||
| M14269 | Ertugliflozin L-pyroglutamic acid | SGLT |
| PF-04971729 L-pyroglutamic acid | ||
| Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. | ||
| M14289 | Lesinurad sodium | URAT1 |
| RDEA-594 sodium | ||
| Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively. | ||
| M14976 | Mulberrin | Others |
| Kuwanon C | ||
| Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM. | ||
| M20793 | Amitriptyline | Serotonin Transporter |
| MK-230; N-750; Ro41575 | ||
| Amitriptyline (MK-230, N-750, Ro41575) is an inhibitor of the serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki values of 3.45 nM and 13.3 nM, respectively, and also inhibits the histamine receptor H1, the histamine receptor H4, 5-HT2, and the Sigma 1 receptor with Ki values of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. It can also inhibit histamine receptor H1, histamine receptor H4, 5-HT2 and Sigma 1 receptor with Ki values of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively, and can be used in studies of depression and neuropathic pain. | ||
| M20997 | Remogliflozin etabonate (GSK189075) | SGLT |
| Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity inhibitor of sodium glucose cotransporter (SGLT2) with Ki of 1950 nM, 2140 nM, 43100 nM, 8570 nM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models. | ||
| M21202 | Recombinant Human Lipocalin-2/NGAL/LCN2 (E. coli, C-6His) | Cytokines and Growth Factors |
| Neutrophil gelatinase-associated lipocalin; NGAL | ||
| Human neutrophil gelatinase-associated lipid transport protein (Lipocalin-2/NGAL/LCN2) is produced by the E. coli expression system and the target gene encoding Gln21-Gly198 has a 6His tag at the C-terminus.Protein number: P80188 | ||
| M21416 | Elobixibat hydrate | Others |
| A 3309 hydrate; AZD 7806 hydrate | ||
| Elobixibat hydrate is a potent bile acid transporter (IBAT) inhibitor with IC50 values of 0.53±0.17 nM (human IBAT), 0.13±0.03 nM (mouse IBAT), and 5.8±1.6 nM (canine IBAT). Elobixibat hydrate can be used in the study of chronic functional constipation (CIC) in the elderly. | ||
| M21722 | Felezonexor (CBS9106) | CRM1 |
| CBS9106; SL-801 | ||
| Felezonexor (CBS9106; SL-801) is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity without affecting CRM1 mRNA levels. Felezonexor is also a reversible inhibitor of XPO1, inhibits nuclear export by covalently binding to Cys528 as well as by inducing the degradation of XPO1. | ||
| M22238 | Emetine dihydrochloride hydrate | Autophagy |
| Emetine dihydrochloride hydrate is an alkaloid that has been found in ipecac root and has diverse biological activities. Emetine inhibits NF-κB signaling induced by TNF-α or IL-1β (IC50s = 2 and 4.2 μM, respectively, in a cell-based β-lactamase reporter assay), increases caspase-3/7 activity in ME180 cells (EC50 = 1.1 μM), and is cytotoxic to HeLa cells. | ||
| M22527 | Cinchonidine | Alkaloids |
| α-Quinidine | ||
| Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. Cinchonidine (α-Quinidine) is a weak inhibitor of serotonin transporter (SERT) with Ki values of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
