Free shipping on all orders over $ 500

JWG-071

Cat. No. M9510
JWG-071 Structure
Size Price Availability
5mg USD 655  USD655 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

JWG-071 is the first reported kinase-selective chemical probe for ERK5, inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively. JWG-071 improves ERK5 activity and BRD4 selectivity.

Chemical Information
Molecular Weight 612.76
Formula C34H44N8O3
CAS Number 2250323-50-1
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wang J, et al. ACS Chem Biol. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.

Related ERK Products
PACAP-38 (31-38), human, mouse, rat

PACAP-38 (31-38), human, mouse, rat is a PAC1 receptor activator and increases the α-secretase activity.

Endothelin-1 (1-31) (Human)

Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent.

ZINC12409120

ZINC12409120 is a high selective ERK inhibitor.

Tizaterkib (hexanedioic acid)

Tizaterkib hexanedioic acid is a potent and selective ERK2 inhibitor, with an IC50 of 0.6 nM.

TAT-MEK1

TAT-MEK1 is an inhibitor ofERK2, consisting of TAT and MEK1 (N-terminal), TAT (YGRKKRRQRRR) derived from human immunodeficiency (HIV-1) transcriptional trans activator (TAT), is a cell-penetrating peptide.

  Catalog
Abmole Inhibitor Catalog




Keywords: JWG-071 supplier, ERK, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.