Free shipping on all orders over $ 500

FR 180204

Cat. No. M3642
FR 180204 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 110  USD110 In stock
5mg USD 95  USD95 In stock
10mg USD 165  USD165 In stock
50mg USD 580  USD580 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

FR180204 inhibited the kinase activity of ERK1 and ERK2, with K(i) values 0.31 and 0.14microM, respectively. FR180204 inhibited TGFbeta-induced luciferase-expression. FR180204 inhibited in vitro CII-induced proliferation of lymph node cells prepared from CII-immunized mice, in which CII-specific T cells are known to undergo specific proliferation.

Protocol (for reference only)
Cell Experiment
Cell lines Met5A, MSTO-211H, NCI-H28, NCI-H2052, and NCIH2452 cell lines
Preparation method Using MTT to assay cell viability . Using a micro-plate reader to quantify MTT-reactive cells at an absorbance of 570 nm.
Concentrations 10 μM
Incubation time 48 hours
Animal Experiment
Animal models Collagen-induced arthritis mouse model
Formulation Suspended in 0.1% methylcellulose solution
Dosages 100 mg/kg
Administration i.p.
Chemical Information
Molecular Weight 327.34
Formula C18H13N7
CAS Number 865362-74-9
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ohori M, et al. Biochem Biophys Res Commun. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex.

Related ERK Products
PACAP-38 (31-38), human, mouse, rat

PACAP-38 (31-38), human, mouse, rat is a PAC1 receptor activator and increases the α-secretase activity.

Endothelin-1 (1-31) (Human)

Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent.

ZINC12409120

ZINC12409120 is a high selective ERK inhibitor.

Tizaterkib (hexanedioic acid)

Tizaterkib hexanedioic acid is a potent and selective ERK2 inhibitor, with an IC50 of 0.6 nM.

TAT-MEK1

TAT-MEK1 is an inhibitor ofERK2, consisting of TAT and MEK1 (N-terminal), TAT (YGRKKRRQRRR) derived from human immunodeficiency (HIV-1) transcriptional trans activator (TAT), is a cell-penetrating peptide.

  Catalog
Abmole Inhibitor Catalog




Keywords: FR 180204 supplier, ERK, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.