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FR180204 inhibited the kinase activity of ERK1 and ERK2, with K(i) values 0.31 and 0.14microM, respectively. FR180204 inhibited TGFbeta-induced luciferase-expression. FR180204 inhibited in vitro CII-induced proliferation of lymph node cells prepared from CII-immunized mice, in which CII-specific T cells are known to undergo specific proliferation.
| Cell Experiment | |
|---|---|
| Cell lines | Met5A, MSTO-211H, NCI-H28, NCI-H2052, and NCIH2452 cell lines |
| Preparation method | Using MTT to assay cell viability . Using a micro-plate reader to quantify MTT-reactive cells at an absorbance of 570 nm. |
| Concentrations | 10 μM |
| Incubation time | 48 hours |
| Animal Experiment | |
|---|---|
| Animal models | Collagen-induced arthritis mouse model |
| Formulation | Suspended in 0.1% methylcellulose solution |
| Dosages | 100 mg/kg |
| Administration | i.p. |
| Molecular Weight | 327.34 |
| Formula | C18H13N7 |
| CAS Number | 865362-74-9 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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