About 30 results found for searched term "ERK" (0.117 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4819 | XMD17-109 | ERK |
| ERK5-IN-1 | ||
| XMD17-109 (ERK5-IN-1) is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 μM in HEK293 cells. | ||
| M9688 | ERK5-IN-2 | ERK |
| ERK5-IN-2 is a selective, orally active, sub-micromolar ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. | ||
| M10733 | Rineterkib | ERK |
| Rineterkib (compound B) is an orally active inhibitor of ERK1/2 that exerts an antiproliferative effect by activating mutations in the MAPK pathway. This activity is particularly associated with KRAS-mutant non-small cell lung cancer, BRAF-mutant non-small cell lung cancer, KRAS-mutant pancreatic cancer, KRAS-mutant colon cancer, and KRAS-mutant ovarian cancer. | ||
| M10741 | ERK1/2 inhibitor 2 | ERK |
| ERK1/2 inhibitor 2 (Example 1) is a potent dual ERK1/2 inhibitor. ERK1/2 inhibitor 2 has anti-cancer activity. | ||
| M10880 | Rineterkib hydrochloride | ERK |
| Rineterkib hydrochloride (compound B) is an orally active inhibitor of ERK1/2 that exerts an antiproliferative effect by activating mutations in the MAPK pathway. This activity is particularly associated with KRAS-mutant non-small cell lung cancer, BRAF-mutant non-small cell lung cancer, KRAS-mutant pancreatic cancer, KRAS-mutant colon cancer, and KRAS mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF. | ||
| M11529 | Temuterkib | ERK |
| LY3214996 | ||
| Temuterkib (LY3214996) is a selective, novel erK1/2 inhibitor with an IC50 of 5 nM against ERK1 and ERK2. It can effectively inhibit intracellular P-RSK1 in cancer cell lines with BRAF and RAS mutations. Temuterkib has strong antitumor activity in cancer models with altered MAPK pathways. | ||
| M14152 | ERK1/2 inhibitor 1 | ERK |
| ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively. | ||
| M20811 | XMD8-85 (ERK5-IN-1) | ERK |
| XMD8-85 (ERK5-IN-1) is a selective and potent inhibitor of ERK5 and LRRK2 with IC50s of 0.162 μM and 0.339 μM, respectively. | ||
| M28985 | AMG PERK 44 | PERK |
| AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively. AMG PERK 44 induces autophagy. | ||
| M41579 | PERK-IN-6 | PERK |
| PERK-IN-6 is a PERK inhibitor with an IC50 of 2.5 nM. | ||
| M42116 | ERK-IN-7 | ERK |
| ERK-IN-7, an analogue of SHR2415, is a potent ERK inhibitor with IC50 of 5 nM and 7 nM against ERK1 and ERK2, respectively. | ||
| M42119 | ERK1/2 inhibitor 9 | ERK |
| ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor. | ||
| M42121 | ERKtide | ERK |
| ERKtide is a biological active peptide. | ||
| M43274 | ERK2 Substrate | Others |
| ERK2 Substrate (Erktide) is a biological active peptide. | ||
| M43456 | ERK-CLIPTAC | PROTAC |
| ERK-CLIPTAC is a PROTAC molecule that triggers the degradation of ERK. | ||
| M45287 | CK2/ERK8-IN-1 | Casein Kinase |
| CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki 0.25 µM) and ERK8 (MAPK15, ERK7), both with IC50s of 0.50 µM. In addition, CK2/ERK8-IN-1 binds to PIM1, HIPK2, and DYRK1A with Ki values of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. 15.25 µM and 11.9 µM, respectively, and also has pro-apoptotic activity. | ||
| M49692 | ERK1/2 inhibitor 7 | ERK |
| ERK1/2 inhibitor 7 is a potent ERK inhibitor with an IC50 of 0.94 nM for ERK2. | ||
| M49693 | ERK-IN-4 | ERK |
| ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM. | ||
| M49699 | Edaxeterkib | ERK |
| Edaxeterkib is a potent extracellular signal-regulated kinase (ERK) inhibitor for the research of cancer. | ||
| M49701 | ERK1/2 inhibitor 3 | ERK |
| ERK1/2 inhibitor 3 is a potent inhibitor of ERK1/2. | ||
| M49702 | ERK1/2 inhibitor 4 | ERK |
| ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2. | ||
| M49703 | ERK1/2 inhibitor 5 | ERK |
| ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2. | ||
| M49704 | ERK1/2 inhibitor 6 | ERK |
| ERK1/2 inhibitor 6 is a potent inhibitor of ERK1/2. | ||
| M49705 | ERK1/2 inhibitor 8 | ERK |
| ERK1/2 inhibitor 8 is a potent ERK inhibitor with an IC50 of 0.48 nM for ERK2. | ||
| M49706 | ERK2 IN-1 | ERK |
| ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM. | ||
| M49707 | ERK2-IN-3 | ERK |
| ERK2-IN-3 is a inhibitor of ERK2, and inhibits Erk2WT and Erk2DS1 activation loop phosphorylation, with IC50 of 5 μM and 42 nM, respectively. | ||
| M49708 | ERK5-IN-3 | ERK |
| ERK5-IN-3 is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. | ||
| M49709 | ERK5-IN-4 | ERK |
| ERK5-IN-4 is a potent and selective inhibitor of extracellular signal-related kinase 5 (ERK5). | ||
| M49710 | ERK5-IN-5 | ERK |
| ERK5-IN-5 is an ERK5 kinase inhibitor with anticancer activity. | ||
| M49711 | ERK5-IN-6 | ERK |
| ERK5-IN-6 is an ERK5 kinase inhibitor with anticancer activity. | ||
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