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 About 30 results found for searched term "ERK" (0.051 seconds)

Cat.No.  Name Target
M4819 XMD17-109 ERK
ERK5-IN-1
XMD17-109 (ERK5-IN-1) is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 μM in HEK293 cells.
M9688 ERK5-IN-2 ERK
ERK5-IN-2 is a selective, orally active, sub-micromolar ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.
M10733 Rineterkib ERK
Rineterkib (compound B) is an orally active inhibitor of ERK1/2 that exerts an antiproliferative effect by activating mutations in the MAPK pathway. This activity is particularly associated with KRAS-mutant non-small cell lung cancer, BRAF-mutant non-small cell lung cancer, KRAS-mutant pancreatic cancer, KRAS-mutant colon cancer, and KRAS-mutant ovarian cancer.
M10741 ERK1/2 inhibitor 2 ERK
ERK1/2 inhibitor 2 (Example 1) is a potent dual ERK1/2 inhibitor. ERK1/2 inhibitor 2 has anti-cancer activity.
M10880 Rineterkib hydrochloride ERK
Rineterkib hydrochloride (compound B) is an orally active inhibitor of ERK1/2 that exerts an antiproliferative effect by activating mutations in the MAPK pathway. This activity is particularly associated with KRAS-mutant non-small cell lung cancer, BRAF-mutant non-small cell lung cancer, KRAS-mutant pancreatic cancer, KRAS-mutant colon cancer, and KRAS mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF.
M11529 Temuterkib ERK
LY3214996
Temuterkib (LY3214996) is a selective, novel erK1/2 inhibitor with an IC50 of 5 nM against ERK1 and ERK2. It can effectively inhibit intracellular P-RSK1 in cancer cell lines with BRAF and RAS mutations. Temuterkib has strong antitumor activity in cancer models with altered MAPK pathways.
M14152 ERK1/2 inhibitor 1 ERK
ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
M20811 XMD8-85 (ERK5-IN-1) ERK
XMD8-85 (ERK5-IN-1) is a selective and potent inhibitor of ERK5 and LRRK2 with IC50s of 0.162 μM and 0.339 μM, respectively.
M28985 AMG PERK 44  PERK
AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively. AMG PERK 44 induces autophagy.
M41579 PERK-IN-6 PERK
PERK-IN-6 is a PERK inhibitor with an IC50 of 2.5 nM.
M42116 ERK-IN-7 ERK
ERK-IN-7, an analogue of SHR2415, is a potent ERK inhibitor with IC50 of 5 nM and 7 nM against ERK1 and ERK2, respectively.
M42119 ERK1/2 inhibitor 9 ERK
ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor.
M42121 ERKtide ERK
ERKtide is a biological active peptide.
M43274 ERK2 Substrate Others
ERK2 Substrate (Erktide) is a biological active peptide.
M43456 ERK-CLIPTAC PROTAC
ERK-CLIPTAC is a PROTAC molecule that triggers the degradation of ERK.
M45287 CK2/ERK8-IN-1 Casein Kinase
CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki 0.25 µM) and ERK8 (MAPK15, ERK7), both with IC50s of 0.50 µM. In addition, CK2/ERK8-IN-1 binds to PIM1, HIPK2, and DYRK1A with Ki values of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. 15.25 µM and 11.9 µM, respectively, and also has pro-apoptotic activity.
M49692 ERK1/2 inhibitor 7 ERK
ERK1/2 inhibitor 7 is a potent ERK inhibitor with an IC50 of 0.94 nM for ERK2.
M49693 ERK-IN-4 ERK
ERK-IN-4 is an ERK inhibitor binds preferentially to ERK2 with a Kd of 5 μM.
M49699 Edaxeterkib ERK
Edaxeterkib is a potent extracellular signal-​regulated kinase (ERK) inhibitor for the research of cancer.
M49701 ERK1/2 inhibitor 3 ERK
ERK1/2 inhibitor 3 is a potent inhibitor of ERK1/2.
M49702 ERK1/2 inhibitor 4 ERK
ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2.
M49703 ERK1/2 inhibitor 5 ERK
ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2.
M49704 ERK1/2 inhibitor 6 ERK
ERK1/2 inhibitor 6 is a potent inhibitor of ERK1/2.
M49705 ERK1/2 inhibitor 8 ERK
ERK1/2 inhibitor 8 is a potent ERK inhibitor with an IC50 of 0.48 nM for ERK2.
M49706 ERK2 IN-1 ERK
ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.
M49707 ERK2-IN-3 ERK
ERK2-IN-3 is a inhibitor of ERK2, and inhibits Erk2WT and Erk2DS1 activation loop phosphorylation, with IC50 of 5 μM and 42 nM, respectively.
M49708 ERK5-IN-3 ERK
ERK5-IN-3 is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM.
M49709 ERK5-IN-4 ERK
ERK5-IN-4 is a potent and selective inhibitor of extracellular signal-related kinase 5 (ERK5).
M49710 ERK5-IN-5 ERK
ERK5-IN-5 is an ERK5 kinase inhibitor with anticancer activity.
M49711 ERK5-IN-6 ERK
ERK5-IN-6 is an ERK5 kinase inhibitor with anticancer activity.



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