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About 30 results found for searched term "ERK" (0.012 seconds)
| Cat.No. | Name | Information |
|---|---|---|
| M1744 | ARRY-162 (Binimetinib) | ARRY-162 (MEK-162; Binimetinib) is a selective, potent inhibitor of MEK and cellular pERK with IC50 of 12 nM and 11 nM, respectively. |
| M1822 | PD98059 | PD98059 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MKK / MEK) with IC50 value of 2-7 μM. The expression of KAT2B protein in cells is significantly decreased after PD98059 inhibits ERK signaling pathway. |
| M1827 | Sorafenib Tosylate | Sorafenib (BAY 43-9006) Tosylate is an orally active multikinase inhibitor of tyrosine protein kinases VEGFR/PDGFR and RAF/MEK/ERK with IC50 values of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. |
| M1977 | U0126-EtOH | U0126-EtOH is a potent and highly selective non-competitive inhibitor of MAPK/ERK kinase with IC50 of 72 nM for MEK1 and 58 nM for MEK2. |
| M2084 | SCH772984 | SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
| M2475 | Bucladesine Sodium Salt | Bucladesine, a membrane permeable selective activator of PKA, has a critical role in up-regulation of ChAT and VAChT gene expression in PC12 cells by activation of extracellular signal regulated kinase (ERK) in Ca2+- and PKA-dependent manner. |
| M2506 | CGP 57380 | CGP 57380 is potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. |
| M2734 | GSK2606414 | GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. |
| M2735 | GSK2656157 | GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM, 500-fold greater against a panel of 300 kinases. |
| M2743 | GW2580 | GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc. |
| M2844 | Methylthiouracil | Methylthiouracil is an anti-thyroid agent. Methylthiouracil inhibits TNF-α and IL-6 production and NF-κB and ERK1/2 activation. |
| M3012 | SKI II | SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2. |
| M3048 | TAK-715 | TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. |
| M3230 | D-87503 | D-87503 inhibits PI3K and Erk2 with IC50 of 62 nM and 760 nM, respectively. |
| M3252 | Tetrabenazine | Tetrabenazine (Nitoman, Xenazine) is a compound for the symptomatic treatment of hyperkinetic movement disorder. |
| M3377 | Honokiol | Honokiol is the active principle of magnolia extract that inhibits Akt-phosphorylation and promotes ERK1/2 phosphorylation. |
| M3642 | FR 180204 | FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively. |
| M3668 | GDC-0994 | Ravoxertinib (GDC-0994) is an orally active ERK kinase inhibitor with IC50 of 6.1 nM and 3.1 nM against ERK1 and ERK2, respectively. |
| M4280 | Corynoxeine | Corynoxeine, isolated from the hook of Uncaria Rhynchophylla, is a potent ERK1/ERK 2 inhibitor in the proliferation of PDGF-BB induced vascular smooth muscle cells (VSMCs). |
| M4380 | Curcumol | Curcumol ((-) -curcumol) is a bioactive sesquiterpene with many pharmacological activities, such as anti-cancer, anti-microbial, anti-fungal, antiviral and anti-inflammatory. Curcumol can effectively induce apoptosis in many cancer cells by targeting key signaling pathways such as MAPK/ERK, PI3K/Akt and NF-κB, which are often abnormally regulated in several cancers. |
| M4428 | Senkyunolide-I | Senkyunolide I can be isolated from Ligusticum chuanxiong Hort and is an antimigraine compound. Senkyunolide I protects rat brain from focal cerebral ischemia-perfusion injury by up-regulating P-ERK1/2, Nrf2/HO-1 and inhibiting Caspase 3. |
| M4676 | LOUREIRIN-B | Loureirin B is a flavonoid isolated from The blood tree of Pterygophyllum SPP. It is an inhibitor of PAI-1 with IC50 value of 26.10 μM. Loureirin B can inhibit the phosphorylation of KATP, ERK and JNK at the same time, showing an anti-diabetes effect. |
| M4705 | Asperosaponin-VI | Asperosaponin-VI induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway. Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB. |
| M4761 | Avicularin | Avicularin is a bioactive flavonoid found in a variety of plants. It has anti-inflammatory, anti-allergy, anti-oxidation, liver protection, anti-tumor and other effects. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. In LPS-stimulated RAW 264.7 macrophages, Avicularin produces anti-inflammatory activity by inhibiting the ERK signaling pathway. |
| M4819 | XMD17-109 | XMD17-109 (ERK5-IN-1) is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 μM in HEK293 cells. |
| M5134 | WAY-181187 | Way-181187 (SAX-187) is an effective selective 5-HT6 receptor agonist with Ki of 2.2 nM and EC50 of 6.6 nM. WAY181187 mediates 5-HT6 receptor-dependent signaling pathways, such as cAMP, Fyn and ERK1/2 kinases, as specific agonists. |
| M5158 | Tauroursodeoxycholic acid（Ursodoxicoltaurine） | Tauroursodeoxycholic acid (Ursodoxicoltaurine) is an endoplasmic reticulum stress inhibitor. It can significantly reduce the expression of apoptotic molecules such as caspase-3 and caspase-12. Tauroursodeoxycholate also suppresses ERK. It is a taurine conjugate of usodeoxycholic acid. |
| M5248 | DEL-22379 | DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM. |
| M5345 | Ulixertinib (BVD-523) | VRT752271 (BVD-523, Ulixertinib) is an orally available, highly selective, ATP-competitive, reversible ERK1/2 inhibitor with an IC50 of <0.3 nM for ERK2 inhibition. |
| M6089 | XMD8-92 | XMD8-92 is a potent and selective BMK1/ERK5 inhibitor with Kd of 80 nM. |
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