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PERK-IN-6

Cat. No. M41579

All AbMole products are for research use only, cannot be used for human consumption.

PERK-IN-6 Structure

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Quality Control & Documentation
Biological Activity

PERK-IN-6 is a PERK inhibitor with an IC50 of 2.5 nM.

Chemical Information
Molecular Weight 398.46
Formula C23H22N6O
CAS Number 1337532-14-5
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
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MK-28 is a potent and selective PERK activator.

PERK-IN-4 

PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC 50 of 0.3 nM.

ML291

ML291 is a first-in-class, potent chemical probe with an EC50 value of 762 nM that selectively activates the PERK/eIF2a/CHOP (apoptosis) arm of the unfolded protein response (UPR) and induces apoptosis in a variety of solid cancer models for leukemia-related studies.

7DG

7DG (7-Desacetoxy-6,7-dehydrogedunin) is a protein kinase R (PKR) inhibitor. 7DG protects macrophages from lethal toxin-induced pyroptosis.

AMG PERK 44 

AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively. AMG PERK 44 induces autophagy.

  Catalog
Abmole Inhibitor Catalog




Keywords: PERK-IN-6 supplier, PERK, inhibitors, activators

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