About 20 results found for searched term "PERK" (0.121 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28985 | AMG PERK 44 | PERK |
| AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively. AMG PERK 44 induces autophagy. | ||
| M41579 | PERK-IN-6 | PERK |
| PERK-IN-6 is a PERK inhibitor with an IC50 of 2.5 nM. | ||
| M56015 | PERK-IN-4 | PERK |
| PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR)-like endoplasmic reticulum kinase) inhibitor with an IC 50 of 0.3 nM. | ||
| M1744 | ARRY-162 (Binimetinib) | MEK |
| MEK-162; Binimetinib; ARRY-438162 | ||
| ARRY-162 (MEK-162; Binimetinib) is a selective, potent inhibitor of MEK and cellular pERK with IC50 of 12 nM and 11 nM, respectively. | ||
| M2734 | GSK2606414 | PERK |
| GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. | ||
| M2735 | GSK2656157 | PERK |
| GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM, 500-fold greater against a panel of 300 kinases. | ||
| M3252 | Tetrabenazine | Monoamine Transporter |
| Xenazine | ||
| Tetrabenazine (Nitoman, Xenazine) is a compound for the symptomatic treatment of hyperkinetic movement disorder. | ||
| M6184 | Dutetrabenazine | Others |
| Tetrabenazine D6; Ro 1-9569 D6 | ||
| Deutetrabenazine is the deuterium labeled Tetrabenazine, which is a VMAT-inhibitor used for the research of hyperkinetic movement disorder. | ||
| M9242 | ISRIB | PERK |
| ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM. | ||
| M10503 | GW284543 (UNC10225170) | MEK |
| UNC10225170 | ||
| GW284543 (UNC10225170) is a selective MEK5 inhibitor, which reduces pERK5 and decreases endogenous MYC protein. | ||
| M13716 | CCT020312 | PERK |
| CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells. | ||
| M16307 | Isogosferol | Immunology/Inflammation |
| Isogosferol is a potent anti-inflammatory agent. Isogosferol decreases LPS-stimulated NO and IL-1β expression. Isogosferol decreases the LPS-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2. | ||
| M20356 | WAY-354896 | PERK |
| WAY-354896 is a Dual activator of Protein Kinase R (PKR) and Protein Kinase R-Like Kinase (PERK). | ||
| M21071 | MAP855 | MEK |
| MAP855 is a potent, selective and orally effective ATP-competitive MEK1/2 kinase inhibitor (MEK1 ERK2 cascade IC50=3 nM, pERK EC50=5 nM). MAP855 inhibits wild-type and mutant MEK1/2 equally. | ||
| M29780 | BAY 2965501 | DGK |
| BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that enhances T cell initiation of suboptimal tumor antigens by inhibiting DGKζ. In addition, BAY 2965501 induces pERK activation.BAY 2965501 can be used in cancer research. | ||
| M31081 | PF-07284892 | Phosphatase |
| ARRY-558 | ||
| PF-07284892 (ARRY-558) is a potent and orally activity SHP2 inhibitor with an IC50 value of 21 nM. PF-07284892 decreases theexpression of pERK. | ||
| M31165 | ML291 | PERK |
| ML-291 | ||
| ML291 is a first-in-class, potent chemical probe with an EC50 value of 762 nM that selectively activates the PERK/eIF2a/CHOP (apoptosis) arm of the unfolded protein response (UPR) and induces apoptosis in a variety of solid cancer models for leukemia-related studies. | ||
| M45317 | (S)-BAY 2965501 | DGK |
| (S)-BAY 2965501 is the left-handed isomer of BAY 2965501 (HY-153343).BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKz) inhibitor and induces pERK activation. BAY 2965501 is a potent and selective inhibitor of diacylglycerol kinase zeta (DGKz) and induces pERK activation. | ||
| M54671 | BTX-6654 | PROTAC |
| BTX-6654 is a targeted and specific cerebellar-based bifunctional SOS1 PROTAC degrader.BTX-6654 reduces the downstream signaling markers pERK and pS6 and displays antiproliferative activity in a wide range of KRAS-mutant cells. In two KRAS G12C xenograft models, BTX-6654 degraded SOS1 in a dose-dependent manner correlating with tumor growth inhibition, additionally exhibiting synergy with KRAS and MEK inhibitors. | ||
| M56016 | MK-28 | PERK |
| MK-28 is a potent and selective PERK activator. | ||
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